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Sustained malaria control over an 8-year period in Papua New Guinea: The challenge of low-density asymptomatic plasmodium infections

Koepfli, Cristian, Ome-Kaius, Maria, Jally, Shadrach, Malau, Elisheba, Maripal, Samuel, Ginny, Jason, Timinao, Lincoln, Kattenberg, Johanna Helena, Obadia, Thomas, White, Michael, Rarau, Patricia, Senn, Nicolas, Barry, Alyssa E., Kazura, James W., Mueller, Ivo and Robinson, Leanne J. 2017, Sustained malaria control over an 8-year period in Papua New Guinea: The challenge of low-density asymptomatic plasmodium infections, Journal of Infectious Diseases, vol. 216, no. 11, pp. 1434-1443, doi: 10.1093/infdis/jix507.

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Title Sustained malaria control over an 8-year period in Papua New Guinea: The challenge of low-density asymptomatic plasmodium infections
Author(s) Koepfli, Cristian
Ome-Kaius, Maria
Jally, Shadrach
Malau, Elisheba
Maripal, Samuel
Ginny, Jason
Timinao, Lincoln
Kattenberg, Johanna Helena
Obadia, Thomas
White, Michael
Rarau, Patricia
Senn, Nicolas
Barry, Alyssa E.ORCID iD for Barry, Alyssa E. orcid.org/0000-0002-1189-2310
Kazura, James W.
Mueller, Ivo
Robinson, Leanne J.
Journal name Journal of Infectious Diseases
Volume number 216
Issue number 11
Start page 1434
End page 1443
Total pages 10
Publisher Oxford Academic
Place of publication Oxford, Eng.
Publication date 2017-12-01
ISSN 0022-1899
1537-6613
Keyword(s) Malaria control
temporal trend
submicroscopic
asymptomatic
gametocyte
Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
Microbiology
GENETIC DIVERSITY
VIVAX INFECTIONS
FALCIPARUM
RELAPSES
EPIDEMIOLOGY
POPULATIONS
PREVALENCE
MOSQUITOS
DYNAMICS
DISEASE
Summary © 2017 The Author. Background. Te scale-up of effective malaria control in the last decade has resulted in a substantial decline in the incidence of clinical malaria in many countries. Te effects on the proportions of asymptomatic and submicroscopic infections and on transmission potential are yet poorly understood. Methods. In Papua New Guinea, vector control has been intensifed since 2008, and improved diagnosis and treatment was introduced in 2012. Cross-sectional surveys were conducted in Madang Province in 2006 (with 1280 survey participants), 2010 (with 2117 participants), and 2014 (with 2516 participants). Infections were quantifed by highly sensitive quantitative polymerase chain reaction (PCR) analysis, and gametocytes were quantifed by reverse-transcription qPCR analysis. Results. Plasmodium falciparum prevalence determined by qPCR decreased from 42% in 2006 to 9% in 2014. Te P. vivax prevalence decreased from 42% in 2006 to 13% in 2010 but then increased to 20% in 2014. Parasite densities decreased 5-fold from 2006 to 2010; 72% of P. falciparum and 87% of P. vivax infections were submicroscopic in 2014. Gametocyte density and positivity correlated closely with parasitemia, and population gametocyte prevalence decreased 3-fold for P. falciparum and 29% for P. vivax from 2010 to 2014. Conclusions. Sustained control has resulted in reduced malaria transmission potential, but an increasing proportion of gametocyte carriers are asymptomatic and submicroscopic and represent a challenge to malaria control.
Language eng
DOI 10.1093/infdis/jix507
Indigenous content off
Field of Research 110899 Medical Microbiology not elsewhere classified
11 Medical and Health Sciences
06 Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30137623

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.