Tunable biodegradable silk-based memory foams with controlled release of antibiotics

Chambre, L, Parker, RN, Allardyce, Benjamin, Valente, F, Rajkhowa, Rangam, Dilley, RJ, Wang, Xungai and Kaplan, DL 2020, Tunable biodegradable silk-based memory foams with controlled release of antibiotics, ACS applied bio materials, vol. 3, no. 4, pp. 2466-2472, doi: 10.1021/acsabm.0c00186.

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Title Tunable biodegradable silk-based memory foams with controlled release of antibiotics
Author(s) Chambre, L
Parker, RN
Allardyce, BenjaminORCID iD for Allardyce, Benjamin orcid.org/0000-0003-4009-3371
Valente, F
Rajkhowa, RangamORCID iD for Rajkhowa, Rangam orcid.org/0000-0002-6811-9126
Dilley, RJ
Wang, XungaiORCID iD for Wang, Xungai orcid.org/0000-0002-3549-6769
Kaplan, DL
Journal name ACS applied bio materials
Volume number 3
Issue number 4
Start page 2466
End page 2472
Total pages 7
Publisher American Chemical Society
Place of publication Washington, D.C.
Publication date 2020
ISSN 2576-6422
Keyword(s) controlled release
silk
biomaterials
antibiotic
degradable
memory foam
Summary Sustained, local delivery of the antibiotic ciprofloxacin under different formats from porous silk protein-based memory foam systems was studied. Similarly, protease XIV was incorporated during processing to provide control of the degradation kinetics of the silk materials. In vitro antibiotic release studies combined with degradation assessments were utilized to assess the mechanisms and kinetics of release from the silk materials. The sequestered protease XIV affected the degradation profiles of the silk foams yet did not impact the release kinetics of the ciprofloxacin, which was controlled by solubility and diffusion of the drug. The ability to tune the release of ciprofloxacin between 1 and 200 days, combined with the option to modulate the degradation rate up to 80% in 2 weeks via incorporation of a protease, suggests utility for drug release devices. Further, we anticipate that this approach could also be extended to other medical implant needs and other drugs.
Language eng
DOI 10.1021/acsabm.0c00186
Field of Research 091205 Functional Materials
Socio Economic Objective 860403 Natural Fibres
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Persistent URL http://hdl.handle.net/10536/DRO/DU:30138011

Document type: Journal Article
Collections: Institute for Frontier Materials
GTP Research
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