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The effect of low carbohydrate diets on fertility hormones and outcomes in overweight and obese women: A systematic review

McGrice, M and Porter, Judi 2017, The effect of low carbohydrate diets on fertility hormones and outcomes in overweight and obese women: A systematic review, Nutrients, vol. 9, no. 3, pp. 1-11, doi: 10.3390/nu9030204.

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Title The effect of low carbohydrate diets on fertility hormones and outcomes in overweight and obese women: A systematic review
Author(s) McGrice, M
Porter, JudiORCID iD for Porter, Judi orcid.org/0000-0002-7535-1919
Journal name Nutrients
Volume number 9
Issue number 3
Start page 1
End page 11
Total pages 11
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2017-02-27
ISSN 2072-6643
Keyword(s) low carbohydrate
ketogenic
polycystic ovarian syndrome
infertile
obese
overweight
systematic review
Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
POLYCYSTIC-OVARY-SYNDROME
LOW-CALORIE DIET
BODY-MASS INDEX
WEIGHT-LOSS
ANOVULATORY INFERTILITY
HYPOCALORIC DIET
MANAGEMENT
METAANALYSES
FAT
Summary (1) Background: Medical interventions including assisted reproductive technologies have improved fertility outcomes for many sub-fertile couples. Increasing research interest has investigated the effect of low carbohydrate diets, with or without energy restriction. We aimed to systematically review the published literature to determine the extent to which low carbohydrate diets can affect fertility outcomes; (2) Methods: The review protocol was registered prospectively with Prospective Register for Systematic Reviews (registration number CRD42016042669) and followed Preferred Reporting Items For Systematic Reviews and Meta-Analyses guidelines. Infertile women were the population of interest, the intervention was low carbohydrate diets (less than 45% total energy from carbohydrates), compared to usual diet (with or without co-treatments). Four databases were searched from date of commencement until April 2016; a supplementary Google scholar search was also undertaken. Title and abstract, then full text review, were undertaken independently and in duplicate. Reference lists of included studies and relevant systematic reviews were checked to ensure that all relevant studies were identified for inclusion. Quality assessment was undertaken independently by both authors using the Quality Criteria Checklist for Primary Research. Outcome measures were improved fertility outcomes defined by an improvement in reproductive hormones, ovulation rates and/or pregnancy rates; (3) Results: Seven studies fulfilled the inclusion criteria and were included in the evidence synthesis. Interventions were diverse and included a combination of low carbohydrate diets with energy deficit or other co-treatments. Study quality was rated as positive for six studies, suggesting a low risk of bias, with one study rated as neutral. Of the six studies which reported changes in reproductive hormones, five reported significant improvements post intervention; (4) Conclusion: The findings of these studies suggest that low carbohydrate diets warrant further research to determine their effect. These randomised controlled trials should consider the effect of carbohydrates (with or without energy deficit) on hormonal and fertility outcomes.
Language eng
DOI 10.3390/nu9030204
Indigenous content off
Field of Research 0908 Food Sciences
1111 Nutrition and Dietetics
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2017, The Author(s)
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30138120

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.