Effect of lean red meat combined with a multicomponent exercise program on muscle and cognitive function in older adults: a 6-month randomized controlled trial

Formica, Melissa B., Gianoudis, Jenny, Nowson, Caryl A., O'Connell, Stella L., Milte, Catherine, Ellis, Kathryn A. and Daly, Robin M. 2020, Effect of lean red meat combined with a multicomponent exercise program on muscle and cognitive function in older adults: a 6-month randomized controlled trial, The American journal of clinical nutrition, vol. 112, no. 1, pp. 113-128, doi: 10.1093/ajcn/nqaa104.

Attached Files
Name Description MIMEType Size Downloads

Title Effect of lean red meat combined with a multicomponent exercise program on muscle and cognitive function in older adults: a 6-month randomized controlled trial
Author(s) Formica, Melissa B.
Gianoudis, Jenny
Nowson, Caryl A.ORCID iD for Nowson, Caryl A. orcid.org/0000-0001-6586-7965
O'Connell, Stella L.
Milte, CatherineORCID iD for Milte, Catherine orcid.org/0000-0003-0035-6405
Ellis, Kathryn A.
Daly, Robin M.ORCID iD for Daly, Robin M. orcid.org/0000-0002-9897-1598
Journal name The American journal of clinical nutrition
Volume number 112
Issue number 1
Start page 113
End page 128
Total pages 16
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2020-07
ISSN 0002-9165
1938-3207
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
lean red meat
dietary protein
exercise
muscle mass
muscle strength
cognitive function
older adults
ADIPOSE-TISSUE DISTRIBUTION
COGSTATE BRIEF BATTERY
PROTEIN SUPPLEMENTATION
RESISTANCE-EXERCISE
DIETARY-PROTEIN
SKELETAL-MUSCLE
DOUBLE-BLIND
PHYSICAL PERFORMANCE
ANABOLIC RESPONSE
FAT INFILTRATION
Summary Background: Exercise and increased dietary protein have been linked to improved muscle and cognitive health, but the combination may be more effective.
Objective: In this study performed in community-dwelling older adults undergoing a 3-d/wk resistance-based exercise training program, we investigated whether those who consumed lean red meat compared to carbohydrates on the 3 training days per wk would experience greater exercise-induced improvements in total body and leg lean mass (LM), muscle strength, and executive function (multiple primary outcomes), as well as muscle size and density, functional performance, cognition, inflammatory and neurotrophic markers, blood pressure, and lipid concentrations.
Design: In a 24-wk, 2-arm parallel randomized controlled trial, 154 adults aged ≥65 y participated in a multicomponent 3-d/wk resistance-based exercise program with random allocation to either a lean red meat group (two 80-g servings of cooked red meat), the exercise plus lean red meat (Ex + Meat) group (n = 77) or a control group receiving carbohydrates in the form of one-half cup (approximately 225 g cooked weight) of rice or pasta or 1 medium potato, the exercise plus carbohydrate control (C + Ex) group (n = 77), on the training days.
Results: Exercise-induced improvements (mean within group changes) did not significantly differ between groups for the primary outcomes of total body LM (0.6 to 0.8 kg), leg LM (0.1 to 0.2 kg), thigh muscle cross-sectional area (3.7% to 4.9%), leg and back muscle strength (26% to 40%), and executive function (z-score SD: 0.33 to 0.39), nor the secondary outcomes of global cognition function (0.17 to 0.23 SD), fat mass (−0.65 to −0.75 kg), physical function measures (sit-to-stand, both 15%; 4-square step test, 2% to 7%), or systolic blood pressure (−3.2 to −4.1 mm Hg). The Ex + Meat group experienced greater improvements than the C + Ex in arm LM (0.07 kg; 95% CI: 0.01, 0.14; P = 0.029), gait speed (0.05 m/s; 95% CI: 0.00, 0.11; P = 0.042), muscle density (1.0%; 95% CI: 0.2, 1.9; P = 0.015), and appendicular LM in the per-protocol analysis (0.21 kg; 95% CI: 0.02, 0.40; P = 0.03). The C + Ex group had greater net improvements in working memory/learning after 12 wk (SD: 0.24; 95% CI: 0.05, 0.43; P = 0.011) and 24 wk (SD: 0.27; 95% CI: 0.06, 0.49; P = 0.007). Inflammatory and neurotrophic markers did not change in either group.
Conclusion: In healthy community-dwelling older adults undertaking resistance-based exercise training 3-d/wk, participants who consumed lean red meat in line with current Australian dietary recommendations did not experience any significant additional benefits in the primary outcome measures of muscle mass, strength, or cognitive function compared to participants consuming carbohydrates.
Language eng
DOI 10.1093/ajcn/nqaa104
Indigenous content off
Field of Research 09 Engineering
11 Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30138187

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in TR Web of Science
Scopus Citation Count Cited 1 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 30 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Fri, 05 Jun 2020, 15:12:06 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.