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Functional nanofibrous biomaterials of tailored structures for drug delivery—a critical review

Li, Zhen, Mei, Shunqi, Dong, Yajie, She, Fenghua, Li, Yongzhen, Li, Puwang and Kong, Lingxue 2020, Functional nanofibrous biomaterials of tailored structures for drug delivery—a critical review, Pharmaceutics, vol. 12, no. 6, pp. 1-23, doi: 10.3390/pharmaceutics12060522.

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Title Functional nanofibrous biomaterials of tailored structures for drug delivery—a critical review
Author(s) Li, Zhen
Mei, Shunqi
Dong, Yajie
She, FenghuaORCID iD for She, Fenghua orcid.org/0000-0001-8191-0820
Li, Yongzhen
Li, Puwang
Kong, LingxueORCID iD for Kong, Lingxue orcid.org/0000-0001-6219-3897
Journal name Pharmaceutics
Volume number 12
Issue number 6
Article ID 522
Start page 1
End page 23
Total pages 23
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2020-06-08
ISSN 1999-4923
Keyword(s) nanofibrous biomaterials
nature fiber biomaterials
biopolymers
drug delivery
nanofiber technology
Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
CELLULOSE-ACETATE
ELECTROSPUN FIBERS
MECHANICAL-PROPERTIES
SURFACE MODIFICATION
CHITOSAN NANOPARTICLES
SILICA NANOPARTICLES
CONTROLLED-RELEASE
CROSS-LINKING
PLGA
COLLAGEN
Summary Nanofibrous biomaterials have huge potential for drug delivery, due to their structural features and functions that are similar to the native extracellular matrix (ECM). A wide range of natural and polymeric materials can be employed to produce nanofibrous biomaterials. This review introduces the major natural and synthetic biomaterials for production of nanofibers that are biocompatible and biodegradable. Different technologies and their corresponding advantages and disadvantages for manufacturing nanofibrous biomaterials for drug delivery were also reported. The morphologies and structures of nanofibers can be tailor-designed and processed by carefully selecting suitable biomaterials and fabrication methods, while the functionality of nanofibrous biomaterials can be improved by modifying the surface. The loading and releasing of drug molecules, which play a significant role in the effectiveness of drug delivery, are also surveyed. This review provides insight into the fabrication of functional polymeric nanofibers for drug delivery.
Language eng
DOI 10.3390/pharmaceutics12060522
Indigenous content off
Field of Research 091205 Functional Materials
1115 Pharmacology and Pharmaceutical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2020, the authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30139262

Document type: Journal Article
Collections: Institute for Frontier Materials
Open Access Collection
GTP Research
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.