Risk of adverse outcomes in females taking oral creatine monohydrate: a systematic review and meta-analysis de Guingand, Deborah L, Palmer, Kirsten R, Snow, Rodney J, Davies-Tuck, Miranda L and Ellery, Stacey J 2020, Risk of adverse outcomes in females taking oral creatine monohydrate: a systematic review and meta-analysis, Nutrients, vol. 12, no. 6, pp. 1-26, doi: 10.3390/nu12061780. Attached Files Name Description MIMEType Size Downloads Title Risk of adverse outcomes in females taking oral creatine monohydrate: a systematic review and meta-analysis Author(s) de Guingand, Deborah L Palmer, Kirsten R Snow, Rodney J orcid.org/0000-0002-4796-6916 Davies-Tuck, Miranda L Ellery, Stacey J Journal name Nutrients Volume number 12 Issue number 6 Article ID 1780 Start page 1 End page 26 Total pages 26 Publisher MDPI Place of publication Basel, Switzerland Publication date 2020-06 ISSN 2072-6643 2072-6643 Keyword(s) Science & Technology Life Sciences & Biomedicine Nutrition & Dietetics creatine monohydrate supplementation adverse outcomes safety human female Summary Creatine Monohydrate (CrM) is a dietary supplement routinely used as an ergogenic aid for sport and training, and as a potential therapeutic aid to augment different disease processes. Despite its increased use in recent years, studies reporting potential adverse outcomes of CrM have been mostly derived from male or mixed sex populations. A systematic search was conducted, which included female participants on CrM, where adverse outcomes were reported, with meta-analysis performed where appropriate. Six hundred and fifty-six studies were identified where creatine supplementation was the primary intervention; fifty-eight were female only studies (9%). Twenty-nine studies monitored for adverse outcomes, with 951 participants. There were no deaths or serious adverse outcomes reported. There were no significant differences in total adverse events, (risk ratio (RR) 1.24 (95% CI 0.51, 2.98)), gastrointestinal events, (RR 1.09 (95% CI 0.53, 2.24)), or weight gain, (mean difference (MD) 1.24 kg pre-intervention, (95% CI −0.34, 2.82)) to 1.37 kg post-intervention (95% CI −0.50, 3.23)), in CrM supplemented females, when stratified by dosing regimen and subject to meta-analysis. No statistically significant difference was reported in measures of renal or hepatic function. In conclusion, mortality and serious adverse events are not associated with CrM supplementation in females. Nor does the use of creatine supplementation increase the risk of total adverse outcomes, weight gain or renal and hepatic complications in females. However, all future studies of creatine supplementation in females should consider surveillance and comprehensive reporting of adverse outcomes to better inform participants and health professionals involved in future trials. Language eng DOI 10.3390/nu12061780 Indigenous content off Field of Research 0908 Food Sciences 1111 Nutrition and Dietetics HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30139379 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Open Access Collection Related Links Link Description Link to full-text (open access)     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Fri, 26 Jun 2020, 08:58:11 EST Sat, 27 Jun 2020, 05:00:16 EST Sun, 28 Jun 2020, 16:51:06 EST Sat, 11 Jul 2020, 02:32:52 EST Sat, 08 Aug 2020, 02:31:27 EST Sat, 15 Aug 2020, 06:04:05 EST Fri, 04 Sep 2020, 14:44:22 EST Fri, 04 Sep 2020, 14:46:03 EST Fri, 04 Sep 2020, 14:46:40 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 7 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Fri, 26 Jun 2020, 08:58:11 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.