Dynamic associations between opioid use and anhedonia: a longitudinal study in opioid dependence

Lubman, Dan I, Garfield, Joshua BB, Gwini, Stella May, Cheetham, Ali, Cotton, Sue M, Yücel, Murat and Allen, Nicholas B 2018, Dynamic associations between opioid use and anhedonia: a longitudinal study in opioid dependence, Journal of psychopharmacology, vol. 32, no. 9, pp. 957-964, doi: 10.1177/0269881118791741.

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Title Dynamic associations between opioid use and anhedonia: a longitudinal study in opioid dependence
Author(s) Lubman, Dan I
Garfield, Joshua BB
Gwini, Stella MayORCID iD for Gwini, Stella May orcid.org/0000-0002-0295-4575
Cheetham, Ali
Cotton, Sue M
Yücel, Murat
Allen, Nicholas B
Journal name Journal of psychopharmacology
Volume number 32
Issue number 9
Start page 957
End page 964
Total pages 8
Publisher SAGE Publications
Place of publication London, Eng.
Publication date 2018-09-01
ISSN 0269-8811
1461-7285
Keyword(s) Anhedonia
opioid use disorder
heroin
Summary Background: Anhedonia is a commonly reported symptom among substance-dependent populations that appears to diminish with sustained abstinence. However, previous research has not determined whether anhedonia is dynamically linked to changing patterns of drug use, nor whether it predicts subsequent drug use. Aims: We aimed to test whether changes in illicit opioid use would predict changes in anhedonia, and whether increases in anhedonia would predict further opioid use. Methods: We conducted a longitudinal, observational study, with a convenience sample of 121 participants with current or past-year Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition Text Revision (DSM-IV-TR) opioid dependence recruited from substance use treatment and related services and from pharmacies administering opioid substitution pharmacotherapy. Anhedonia was assessed with the Temporal Experience of Pleasure Scale and frequency of illicit opioid use was assessed using timeline follow-back interviews. Results: There was a significant within-subject effect (β=−0.015; 95% CI −0.02 to −0.01; p=0.001), indicating that participants’ Temporal Experience of Pleasure Scale scores typically declined (i.e. anhedonia increased) following a month with above-average opioid use and Temporal Experience of Pleasure Scale scores rose (i.e. anhedonia reduced) following a month with below-average opioid use. However, Temporal Experience of Pleasure Scale scores did not significantly predict opioid use in the subsequent month (β=−0.04, 95% CI −0.20 to 0.12; p=0.651). Conclusions: Changes in illicit opioid use predict self-reported anhedonia, suggesting a possible causal relationship whereby anhedonia is likely to worsen with frequent drug use and diminish with prolonged abstinence. However, anhedonia does not appear to drive further drug use.
Language eng
DOI 10.1177/0269881118791741
Indigenous content off
Field of Research 11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30139519

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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