Proinflammatory diet increases circulating inflammatory biomarkers and falls risk in community-dwelling older men

Cervo, Mavil May C., Scott, David, Seibel, Markus J., Cumming, Robert G., Naganathan, Vasi, Blyth, Fiona M., Le Couteur, David G., Handelsman, David J., Ribeiro, Rosilene V., Waite, Louise M., Shivappa, Nitin, Hebert, James R. and Hirani, Vasant 2020, Proinflammatory diet increases circulating inflammatory biomarkers and falls risk in community-dwelling older men, Journal of nutrition, vol. 150, no. 2, pp. 373-381, doi: 10.1093/jn/nxz256.

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Title Proinflammatory diet increases circulating inflammatory biomarkers and falls risk in community-dwelling older men
Author(s) Cervo, Mavil May C.
Scott, David
Seibel, Markus J.
Cumming, Robert G.
Naganathan, Vasi
Blyth, Fiona M.
Le Couteur, David G.
Handelsman, David J.
Ribeiro, Rosilene V.
Waite, Louise M.
Shivappa, Nitin
Hebert, James R.
Hirani, Vasant
Journal name Journal of nutrition
Volume number 150
Issue number 2
Start page 373
End page 381
Total pages 9
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2020-02
ISSN 0022-3166
1541-6100
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
dietary inflammatory index
chronic inflammation
inflammatory biomarkers
bone mineral density
falls
community-dwelling older men
BONE-MINERAL DENSITY
C-REACTIVE PROTEIN
POSTMENOPAUSAL WOMEN
CONCORD HEALTH
MULTIPLE-SCLEROSIS
FRACTURE RISK
HIP FRACTURE
INDEX
MARKERS
AUSTRALIA
Summary Background: The relations between diet, chronic inflammation, and musculoskeletal health are unclear, especially among older men. Objective: This study aimed to determine associations of the Dietary Inflammatory Index (DII) with inflammatory biomarkers, musculoskeletal health, and falls risk in community-dwelling older men. Methods: The cross-sectional analysis included 794 community-dwelling men, mean age 81.1 ± 4.5 y, who participated in the 5-y follow-up of the Concord Health and Aging in Men Project. Of these, 616 were seen again 3 y later for the longitudinal analysis. Energy-adjusted DII (E-DII) was calculated from a validated diet history questionnaire. Bone mineral density (BMD) was measured using DXA. Twenty-four inflammatory biomarkers were analyzed. Incident falls over 3 y were determined through telephone interviews every 4 mo. Multiple regression, linear mixed effects models, negative binomial regression, and mediation analysis were utilized in this study. Results: A higher E-DII score (indicating a more proinflammatory diet) was associated with higher concentrations of IL-6 (β: 0.028 pg/mL; 95% CI: 0.003, 0.053), IL-7 (β: 0.020 pg/mL; 95% CI: 0.002, 0.037), and TNF-α (β: 0.027 pg/mL; 95% CI: 0.003, 0.051). A higher E-DII score was also associated with lower appendicular lean mass adjusted for BMI (ALMBMI) (β: −0.006 kg/m2; 95% CI: −0.010, −0.001). For every unit increase in E-DII (range: −4.91 to +3.66 units), incident falls rates increased by 13% (incidence rate ratio: 1.13; 95% CI: 1.05, 1.21) over 3 y. Mediation analysis showed that the association between E-DII and 3-y incident falls was influenced by the concentrations of IL-7 by 24%. There was no association between E-DII and BMD. Conclusions: Consumption of a proinflammatory diet was associated with increased concentrations of IL-6, IL-7, and TNF-α; increased falls risk; and lower ALMBMI in community-dwelling older men. The association between incident falls and E-DII was partly mediated by concentrations of IL-7.
Language eng
DOI 10.1093/jn/nxz256
Indigenous content off
Field of Research 1111 Nutrition and Dietetics
0702 Animal Production
0908 Food Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30139940

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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