The effect of yearly-dose vitamin D supplementation on muscle function in mice Hayes, Alan, Rybalka, Emma, Debruin, Danielle A., Hanson, Erik D., Scott, David and Sanders, Kerrie 2019, The effect of yearly-dose vitamin D supplementation on muscle function in mice, Nutrients, vol. 11, no. 5, pp. 1-10, doi: 10.3390/nu11051097. Attached Files Name Description MIMEType Size Downloads Title The effect of yearly-dose vitamin D supplementation on muscle function in mice Author(s) Hayes, Alan Rybalka, Emma Debruin, Danielle A. Hanson, Erik D. Scott, David Sanders, Kerrie Journal name Nutrients Volume number 11 Issue number 5 Article ID 1097 Start page 1 End page 10 Total pages 10 Publisher MDPI Place of publication Basel, Switzerland Publication date 2019-05-17 ISSN 2072-6643 2072-6643 Keyword(s) Science & Technology Life Sciences & Biomedicine Nutrition & Dietetics cholecalciferol vitamin D muscle function muscle fatigue MINIMUM FOOT CLEARANCE DOUBLE-BLIND D DEFICIENCY OLDER WOMEN FALLS FRACTURES FATIGUE WALKING RISK MEN Summary Supplementation with vitamin D helps to alleviate weakness and fatigue seen with deficiency. However, large bolus doses appear to worsen the risk of falls. Whether this occurs as a direct result of muscle weakness is currently unknown. Thus, the aims of this study were to examine the muscle function following administration of high doses of vitamin D. Given the safety issues associated with bolus doses, experiments were conducted on C57BL6 mice. Mice at eight weeks of age with otherwise normal levels of vitamin D were supplemented for four weeks with a high dose (HIGH; n = 12) of vitamin D (20000 IU/kg food) designed to provide a year’s worth of vitamin D. These mice were compared to another group who received that same yearly dose in a single bolus i.p. injection (YEAR; n = 12). Mice provided with standard mouse chow, which contained 1000 IU/kg food, and injected with the vitamin D vehicle were used as controls (CON; n = 16). Force and fatigue properties of hind limb fast- and slow-twitch muscles were measured. CON animals ingested vitamin D consistent with typical human supplementation. HIGH animals consumed significantly more food than the CON animals, such that they ingested more than a year’s worth of vitamin D in four weeks. Despite this, there were few differences in the muscle function compared with CON. YEAR animals demonstrated lower absolute and relative forces in both muscles compared to the HIGH animals, as well as lower force during fatigue and early recovery. Large bolus doses of vitamin D appear to have detrimental effects on the skeletal muscle function, likely being a contributor to increased risk of falls observed with similar doses in humans. Mice ingesting the same amount over four weeks did not demonstrate the same deleterious effects, suggesting this may be a safe way to provide high vitamin D if required. Language eng DOI 10.3390/nu11051097 Indigenous content off Field of Research 0908 Food Sciences 1111 Nutrition and Dietetics HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30139983 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Open Access Collection Related Links Link Description Link to full-text (open access)     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Fri, 10 Jul 2020, 15:36:40 EST Sat, 11 Jul 2020, 05:03:45 EST Mon, 13 Jul 2020, 08:09:46 EST Sat, 08 Aug 2020, 06:04:09 EST Thu, 03 Sep 2020, 14:21:05 EST Thu, 03 Sep 2020, 14:24:50 EST Filtered Full Citation counts:   Cited 1 times in TR Web of Science Cited 1 times in Scopus Search Google Scholar Access Statistics: 13 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Fri, 10 Jul 2020, 15:36:40 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.