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Abdominal aortic calcification, bone mineral density and fractures: A systematic review and meta-Analysis protocol

Rodríguez, AJ, Leow, K, Szulc, P, Scott, David, Ebeling, P, Sim, M, Wong, G, Lim, WH, Schousboe, JT, Kiel, DP, Prince, RL and Lewis, JR 2019, Abdominal aortic calcification, bone mineral density and fractures: A systematic review and meta-Analysis protocol, BMJ Open, vol. 9, no. 4, pp. 1-5, doi: 10.1136/bmjopen-2018-026232.

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Title Abdominal aortic calcification, bone mineral density and fractures: A systematic review and meta-Analysis protocol
Author(s) Rodríguez, AJ
Leow, K
Szulc, P
Scott, DavidORCID iD for Scott, David orcid.org/0000-0001-5226-1972
Ebeling, P
Sim, M
Wong, G
Lim, WH
Schousboe, JT
Kiel, DP
Prince, RL
Lewis, JR
Journal name BMJ Open
Volume number 9
Issue number 4
Article ID e026232
Start page 1
End page 5
Total pages 5
Publisher BMJ
Place of publication London, Eng.
Publication date 2019-04-02
ISSN 2044-6055
Keyword(s) abdominal aorta
bone mineral density
fracture
vascular calcification
vascular disease
Summary Introduction: Abdominal aortic calcification (AAC) is associated with low bone mass and increased fracture risk. Two previous meta-Analyses have investigated the association between AAC and fracture. However, these meta-Analyses only identified articles until December 2016, undertook limited searches and did not explore potential sources of between-study heterogeneity. We aim to undertake a sensitive and comprehensive assessment of the relationship between AAC, bone mineral density (BMD) as well as prevalent and incident fractures. Methods: We will search MEDLINE, EMBASE, Web of Science core collection and Google Scholar (top 200 articles sorted by relevance) from their inception to 1 June 2018. Reference lists of included studies and previous systematic reviews will be hand searched for additional eligible studies. Retrospective and prospective cohort studies (cross-sectional, case-control and longitudinal) reporting the association between AAC, BMD and fracture at any site will be included. At least two investigators will independently: (A) evaluate study eligibility and extract data, with a third investigator to adjudicate when discrepancies occur, (B) assess study quality by the Newcastle-Ottawa Scale for each cohort/study. The meta-Analysis will be reported in adherence to the Meta-Analysis of Observational Studies in Epidemiology criteria. AAC will be grouped as either: (1) AAC present or absent, (2) AAC categorised as â € low' (referent-lowest reported group) versus â € high' (all other groups) or (3) dose-response when AAC was assessed in ≥3 groups. Where primary event data were reported in individual studies, pooled risk differences and risk ratios with 95% CI will be calculated, from which, a summary estimate will be determined using DerSimonian-Laird random effects models. For the AAC and BMD pooled analyses, estimates will be expressed as standardised mean difference with 95% CI. We will examine the likelihood of publication bias and where possible, investigate potential reasons for between-study heterogeneity using subgroup analyses and meta-regression. Ethics and dissemination: The study will be submitted to a peer-reviewed journal and disseminated via research presentations. PROSPERO registration number: CRD42018088019.
Language eng
DOI 10.1136/bmjopen-2018-026232
Indigenous content off
Field of Research 1103 Clinical Sciences
1117 Public Health and Health Services
1199 Other Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, Author(s) (or their employer(s))
Free to Read? Yes
Use Rights Creative Commons Attribution non-commercial licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30139987

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.