National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: A pooled analysis of 458 population-based studies in Asian and Western countries Taddei, Cristina, Jackson, Rod, Zhou, Bin, Bixby, Honor, Danaei, Goodarz, Di Cesare, Mariachiara, Kuulasmaa, Kari, Hajifathalian, Kaveh, Bentham, James, Bennett, James E., Aekplakorn, Wichai, Cifkova, Renata, Dallongeville, Jean, Debacquer, Dirk, Giampaoli, Simona, Gudnason, Vilmundur, Khang, Young-Ho, Laatikainen, Tiina, Mann, Jim I. and Tan, Eng Joo 2020, National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: A pooled analysis of 458 population-based studies in Asian and Western countries, International Journal of Epidemiology, vol. 49, no. 1, pp. 173-192, doi: 10.1093/ije/dyz099. Attached Files Name Description MIMEType Size Downloads Title National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: A pooled analysis of 458 population-based studies in Asian and Western countries Author(s) Taddei, Cristina Jackson, Rod Zhou, Bin Bixby, Honor Danaei, Goodarz Di Cesare, Mariachiara Kuulasmaa, Kari Hajifathalian, Kaveh Bentham, James Bennett, James E. Aekplakorn, Wichai Cifkova, Renata Dallongeville, Jean Debacquer, Dirk Giampaoli, Simona Gudnason, Vilmundur Khang, Young-Ho Laatikainen, Tiina Mann, Jim I. Tan, Eng Joo orcid.org/0000-0003-4449-4404 Journal name International Journal of Epidemiology Volume number 49 Issue number 1 Start page 173 End page 192 Total pages 20 Publisher Oxford University Press Place of publication Oxford, Eng. Publication date 2020-02-01 ISSN 0300-5771 1464-3685 Keyword(s) Science & Technology Life Sciences & Biomedicine Public, Environmental & Occupational Health Total cholesterol LDL cholesterol HDL cholesterol blood lipids multi-country study HIGH-DENSITY-LIPOPROTEIN CARDIOVASCULAR RISK-FACTORS CORONARY-HEART-DISEASE INDIVIDUAL DATA BLOOD-PRESSURE WORLDWIDE TRENDS SERUM-LIPIDS DIETARY-FAT METAANALYSIS NCD Risk Factor Collaboration (NCD-RisC) Summary Background: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries.Methods: We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group.Results: Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China.Conclusions: HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol. Language eng DOI 10.1093/ije/dyz099 Indigenous content off Field of Research 0104 Statistics 1117 Public Health and Health Services HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30140073 Document type: Journal Article Collections: Faculty of Health School of Health and Social Development Open Access Collection Related Links Link Description Link to full-text (open access)     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Thu, 16 Jul 2020, 16:15:10 EST Fri, 17 Jul 2020, 05:00:41 EST Tue, 04 Aug 2020, 06:04:31 EST Sat, 15 Aug 2020, 02:31:28 EST Mon, 31 Aug 2020, 16:13:57 EST Mon, 31 Aug 2020, 16:19:03 EST Mon, 31 Aug 2020, 16:20:24 EST Mon, 31 Aug 2020, 16:26:56 EST Filtered Full Citation counts:   Cited 6 times in TR Web of Science Cited 7 times in Scopus Search Google Scholar Access Statistics: 12 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Thu, 16 Jul 2020, 16:15:10 EST

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