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National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: A pooled analysis of 458 population-based studies in Asian and Western countries

Taddei, Cristina, Jackson, Rod, Zhou, Bin, Bixby, Honor, Danaei, Goodarz, Di Cesare, Mariachiara, Kuulasmaa, Kari, Hajifathalian, Kaveh, Bentham, James, Bennett, James E., Aekplakorn, Wichai, Cifkova, Renata, Dallongeville, Jean, Debacquer, Dirk, Giampaoli, Simona, Gudnason, Vilmundur, Khang, Young-Ho, Laatikainen, Tiina, Mann, Jim I. and Tan, Eng Joo 2020, National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: A pooled analysis of 458 population-based studies in Asian and Western countries, International Journal of Epidemiology, vol. 49, no. 1, pp. 173-192, doi: 10.1093/ije/dyz099.

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Title National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: A pooled analysis of 458 population-based studies in Asian and Western countries
Author(s) Taddei, Cristina
Jackson, Rod
Zhou, Bin
Bixby, Honor
Danaei, Goodarz
Di Cesare, Mariachiara
Kuulasmaa, Kari
Hajifathalian, Kaveh
Bentham, James
Bennett, James E.
Aekplakorn, Wichai
Cifkova, Renata
Dallongeville, Jean
Debacquer, Dirk
Giampaoli, Simona
Gudnason, Vilmundur
Khang, Young-Ho
Laatikainen, Tiina
Mann, Jim I.
Tan, Eng JooORCID iD for Tan, Eng Joo orcid.org/0000-0003-4449-4404
Journal name International Journal of Epidemiology
Volume number 49
Issue number 1
Start page 173
End page 192
Total pages 20
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2020-02-01
ISSN 0300-5771
1464-3685
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Public, Environmental & Occupational Health
Total cholesterol
LDL cholesterol
HDL cholesterol
blood lipids
multi-country study
HIGH-DENSITY-LIPOPROTEIN
CARDIOVASCULAR RISK-FACTORS
CORONARY-HEART-DISEASE
INDIVIDUAL DATA
BLOOD-PRESSURE
WORLDWIDE TRENDS
SERUM-LIPIDS
DIETARY-FAT
METAANALYSIS
NCD Risk Factor Collaboration (NCD-RisC)
Summary Background: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries.Methods: We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group.Results: Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China.Conclusions: HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol.
Language eng
DOI 10.1093/ije/dyz099
Indigenous content off
Field of Research 0104 Statistics
1117 Public Health and Health Services
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30140073

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.