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A systematic review and meta-analysis of B vitamin supplementation on depressive symptoms, anxiety, and stress: effects on healthy and 'at-risk' individuals

Young, Lauren M, Pipingas, Andrew, White, David J, Gauci, Sarah and Scholey, Andrew 2019, A systematic review and meta-analysis of B vitamin supplementation on depressive symptoms, anxiety, and stress: effects on healthy and 'at-risk' individuals, Nutrients, vol. 11, no. 9, pp. 1-19, doi: 10.3390/nu11092232.

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Title A systematic review and meta-analysis of B vitamin supplementation on depressive symptoms, anxiety, and stress: effects on healthy and 'at-risk' individuals
Author(s) Young, Lauren MORCID iD for Young, Lauren M orcid.org/0000-0002-2020-0400
Pipingas, Andrew
White, David J
Gauci, Sarah
Scholey, Andrew
Journal name Nutrients
Volume number 11
Issue number 9
Article ID 2232
Start page 1
End page 19
Total pages 19
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2019-09
ISSN 2072-6643
2072-6643
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
B-vitamins
mood
meta-analysis
review
mental health
stress
anxiety
depression
Summary A systematic review and meta-analysis was undertaken to examine and quantify the effects of B vitamin supplementation on mood in both healthy and ‘at-risk’ populations. A systematic search identified all available randomised controlled trials (RCTs) of daily supplementation with ≥3 B group vitamins with an intervention period of at least four weeks. Random effects models for a standardized mean difference were used to test for overall effect. Heterogeneity was tested using the I2 statistic. Eighteen articles (16 trials, 2015 participants) were included, of which 12 were eligible for meta-analysis. Eleven of the 18 articles reported a positive effect for B vitamins over a placebo for overall mood or a facet of mood. Of the eight studies in ‘at-risk’ cohorts, five found a significant benefit to mood. Regarding individual facets of mood, B vitamin supplementation benefited stress (n = 958, SMD = 0.23, 95% CI = 0.02, 0.45, p = 0.03). A benefit to depressive symptoms did not reach significance (n = 568, SMD = 0.15, 95% CI = −0.01, 0.32, p = 0.07), and there was no effect on anxiety (n = 562, SMD = 0.03, 95% CI = −0.13, 0.20, p = 0.71). The review provides evidence for the benefit of B vitamin supplementation in healthy and at-risk populations for stress, but not for depressive symptoms or anxiety. B vitamin supplementation may particularly benefit populations who are at risk due to (1) poor nutrient status or (2) poor mood status.
Language eng
DOI 10.3390/nu11092232
Indigenous content off
Field of Research 0908 Food Sciences
1111 Nutrition and Dietetics
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30140457

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.