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MicroRNA Biomarkers for Infectious Diseases: From Basic Research to Biosensing

Tribolet, Leon, Kerr, Emily, Cowled, Christopher, Bean, Andrew G. D., Stewart, Cameron R., Dearnley, Megan and Farr, Ryan J. 2020, MicroRNA Biomarkers for Infectious Diseases: From Basic Research to Biosensing, Frontiers in Microbiology, vol. 11, pp. 1-15, doi: 10.3389/fmicb.2020.01197.

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Title MicroRNA Biomarkers for Infectious Diseases: From Basic Research to Biosensing
Author(s) Tribolet, Leon
Kerr, Emily
Cowled, Christopher
Bean, Andrew G. D.
Stewart, Cameron R.
Dearnley, Megan
Farr, Ryan J.
Journal name Frontiers in Microbiology
Volume number 11
Article ID 1197
Start page 1
End page 15
Total pages 15
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2020-06-03
ISSN 1664-302X
1664-302X
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Microbiology
microRNAs
infectious disease
diagnostics
biomarkers
personalized medicine
CIRCULATING MICRORNAS
ELECTROCHEMICAL BIOSENSOR
VISUAL DETECTION
VIRUS-INFECTION
RNA EXTRACTION
MESSENGER-RNA
SERUM
EXPRESSION
DIAGNOSIS
HIV
Summary In the pursuit of improved diagnostic tests for infectious diseases, several classes of molecules have been scrutinized as prospective biomarkers. Small (18–22 nucleotide), non-coding RNA transcripts called microRNAs (miRNAs) have emerged as promising candidates with extensive diagnostic potential, due to their role in numerous diseases, previously established methods for quantitation and their stability within biofluids. Despite efforts to identify, characterize and apply miRNA signatures as diagnostic markers in a range of non-infectious diseases, their application in infectious disease has advanced relatively slowly. Here, we outline the benefits that miRNA biomarkers offer to the diagnosis, management, and treatment of infectious diseases. Investigation of these novel biomarkers could advance the use of personalized medicine in infectious disease treatment, which raises important considerations for validating their use as diagnostic or prognostic markers. Finally, we discuss new and emerging miRNA detection platforms, with a focus on rapid, point-of-care testing, to evaluate the benefits and obstacles of miRNA biomarkers for infectious disease.
Language eng
DOI 10.3389/fmicb.2020.01197
Indigenous content off
Field of Research 060502 Infectious Agents
0502 Environmental Science and Management
0503 Soil Sciences
0605 Microbiology
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2020, Tribolet, Kerr, Cowled, Bean, Stewart, Dearnley and Farr
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30140565

Document type: Journal Article
Collections: Institute for Frontier Materials
Open Access Collection
GTP Research
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.