Impact of axial eye size on retinal microvasculature density in the macular region Khan, M Hafi, Lam, Andrew KC, Armitage, James A, Hanna, Lisa, To, Chi-Ho and Gentle, Alex 2020, Impact of axial eye size on retinal microvasculature density in the macular region, Journal of clinical medicine, vol. 9, no. 8, pp. 1-15, doi: 10.3390/jcm9082539. Attached Files Name Description MIMEType Size Downloads Title Impact of axial eye size on retinal microvasculature density in the macular region Author(s) Khan, M Hafi Lam, Andrew KC Armitage, James A orcid.org/0000-0002-3762-0911 Hanna, Lisa orcid.org/0000-0003-3173-3381 To, Chi-Ho Gentle, Alex orcid.org/0000-0003-0661-4196 Journal name Journal of clinical medicine Volume number 9 Issue number 8 Article ID 2539 Start page 1 End page 15 Total pages 15 Publisher MDPI Place of publication Basel, Switzerland Publication date 2020-08 ISSN 2077-0383 2077-0383 Keyword(s) Science & Technology Life Sciences & Biomedicine Medicine, General & Internal General & Internal Medicine refractive error myopia eye size optical coherence tomography angiography (OCTA) retina retinal perfusion vascular perfusion Summary Mechanical tissue stresses are important contributors to the increased risk of sight-threatening pathology in larger, more myopic eyes. The contribution of altered ocular vasculature to the development of this pathology is less well defined. The current study investigated the impact of eye size on the superficial vasculature of the macula. Subjects (n = 104) aged 18–50, with no history of ocular or vascular disease, or myopia control, were recruited from university staff and student populations in Australia and Hong Kong. Refractive error, ocular size, retinal morphology and vascular morphology were quantified through open field autorefraction, ocular biometry and ocular coherence tomography angiography. Morphology of the superficial retinal capillary plexus was assessed over a 3 × 3 mm fovea-centred area. Perfusion area and vessel length densities were analysed relative to axial eye length and retinal thickness. A significant inverse association was found between axial length and vascular density measures (perfusion area density r2 = 0.186, p < 0.001; and vessel length density r2 = 0.102, p = 0.001). Perfusion area and vessel length densities were reduced by 5.8% (p = 0.001) in the longest, relative to the shortest, eyes. The aggregated ganglion cell layer inner plexiform layer thickness was also inversely associated with eye size (r2 = 0.083, p = 0.003), and reduced, by 8.1% (p < 0.001), in the longest eyes. An inverse association of eye size and superficial retinal vasculature density, that is not simply explained by retinal expansion or image magnification factors, was confirmed. These data support the hypothesis that ongoing metabolic challenges may underlie the development of myopia-related and -associated pathology in larger eyes. Language eng DOI 10.3390/jcm9082539 Indigenous content off Field of Research 1103 Clinical Sciences HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30140820 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Link to full-text (open-access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Thu, 13 Aug 2020, 20:42:55 EST Fri, 14 Aug 2020, 05:01:22 EST Fri, 14 Aug 2020, 06:03:51 EST Mon, 17 Aug 2020, 12:14:32 EST Sat, 03 Oct 2020, 02:30:06 EST Tue, 02 Mar 2021, 05:04:42 EST Mon, 08 Mar 2021, 10:04:26 EST Mon, 08 Mar 2021, 10:07:28 EST Mon, 08 Mar 2021, 14:49:18 EST Filtered Full Citation counts:   Cited 1 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 21 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Thu, 13 Aug 2020, 20:42:55 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.