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Fixel based analysis reveals atypical white matter micro- and macrostructure in adults with autism spectrum disorder: an investigation of the role of biological sex

Kirkovski, M, Fuelscher, Ian, Hyde, Christian, Donaldson, Peter, Ford, TC, Rossell, SL, Fitzgerald, PB and Enticott, PG 2020, Fixel based analysis reveals atypical white matter micro- and macrostructure in adults with autism spectrum disorder: an investigation of the role of biological sex, Frontiers in integrative neuroscience, vol. 14, pp. 1-11, doi: 10.3389/fnint.2020.00040.

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Title Fixel based analysis reveals atypical white matter micro- and macrostructure in adults with autism spectrum disorder: an investigation of the role of biological sex
Author(s) Kirkovski, M
Fuelscher, IanORCID iD for Fuelscher, Ian orcid.org/0000-0002-4875-0105
Hyde, ChristianORCID iD for Hyde, Christian orcid.org/0000-0003-4833-4782
Donaldson, PeterORCID iD for Donaldson, Peter orcid.org/0000-0001-7715-8891
Ford, TC
Rossell, SL
Fitzgerald, PB
Enticott, PG
Journal name Frontiers in integrative neuroscience
Volume number 14
Article ID 40
Start page 1
End page 11
Total pages 11
Publisher Frontiers Research Foundation
Place of publication Lausanne, Switzerland
Publication date 2020-08
ISSN 1662-5145
Keyword(s) autism spectrum disorder
fixel based analysis
biological sex
fiber density and cross-section
corpus callosum
Summary Atypical white matter (WM) microstructure is commonly implicated in the neuropathophysiology of autism spectrum disorder (ASD). Fixel based analysis (FBA), at the cutting-edge of diffusion-weighted imaging, can account for crossing WM fibers and can provide indices of both WM micro- and macrostructure. We applied FBA to investigate WM structure between 25 (12 males, 13 females) adults with ASD and 24 (12 males, 12 females) matched controls. As the role of biological sex on the neuropathophysiology of ASD is of increasing interest, this was also explored. There were no significant differences in WM micro- or macrostructure between adults with ASD and matched healthy controls. When data were stratified by sex, females with ASD had reduced fiber density and cross-section (FDC), a combined metric comprised of micro- and macrostructural measures, in the corpus callosum, a finding not detected between the male sub-groups. We conclude that micro- and macrostructural WM aberrations are present in ASD, and may be influenced by biological sex.
Language eng
DOI 10.3389/fnint.2020.00040
Field of Research 1109 Neurosciences
1701 Psychology
1702 Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30140827

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
Open Access Collection
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Created: Fri, 14 Aug 2020, 06:34:34 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.