Association between Maternal Iodine Intake in Pregnancy and Childhood Neurodevelopment at Age 18 Months Zhou, Shao J., Condo, Dominique, Ryan, Philip, Skeaff, Sheila A., Howell, Stuart, Anderson, Peter J., McPhee, Andrew J. and Makrides, Maria 2019, Association between Maternal Iodine Intake in Pregnancy and Childhood Neurodevelopment at Age 18 Months, American Journal of Epidemiology, vol. 188, no. 2, pp. 332-338, doi: 10.1093/aje/kwy225. Attached Files Name Description MIMEType Size Downloads Title Association between Maternal Iodine Intake in Pregnancy and Childhood Neurodevelopment at Age 18 Months Author(s) Zhou, Shao J. Condo, Dominique orcid.org/0000-0002-8348-7488 Ryan, Philip Skeaff, Sheila A. Howell, Stuart Anderson, Peter J. McPhee, Andrew J. Makrides, Maria Journal name American Journal of Epidemiology Volume number 188 Issue number 2 Start page 332 End page 338 Total pages 7 Publisher Oxford Academic Place of publication Oxford, Eng. Publication date 2019-02 ISSN 0002-9262 1476-6256 Keyword(s) Bayley Scales child development iodine deficiency iodine intake pregnancy urinary iodine concentration Summary © The Author(s) 2018. There are limited and inconsistent data suggesting that mild iodine deficiency in pregnancy might be associated with poorer developmental outcomes in children. Between 2011 and 2015, we conducted a prospective cohort study in Australia examining the relationship between maternal iodine intake in pregnancy and childhood neurodevelopment, assessed using Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III), in 699 children at 18 months. Maternal iodine intake and urinary iodine concentration (UIC) were assessed at study entry (<20 weeks' gestation) and at 28 weeks' gestation. Maternal iodine intake in the lowest (<220 μg/day) or highest (≥391 μg/day) quartile was associated with lower cognitive, language, and motor scores (mean differences ranged from 2.4 (95% confidence interval (CI): 0.01, 4.8) to 7.0 (95% CI: 2.8, 11.1) points lower) and higher odds (odds ratios ranged from 2.7 (95% CI: 1.3, 5.6) to 2.8 (95% CI: 1.3, 5.7)) of cognitive developmental delay (Bayley-III score <85) compared with mothers with an iodine intake in the middle quartiles. There was no association between UIC in pregnancy and Bayley-III outcomes regardless of whether UIC and the outcomes were analyzed as continuous or categorical variables. Both low and high iodine intakes in pregnancy were associated with poorer childhood neurodevelopment in this iodine-sufficient population. Language eng DOI 10.1093/aje/kwy225 Indigenous content off Field of Research 111704 Community Child Health 01 Mathematical Sciences 11 Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30140996 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Open Access Collection Related Links Link Description Link to full-text (open access)     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Thu, 20 Aug 2020, 13:02:11 EST Fri, 21 Aug 2020, 05:01:41 EST Sat, 22 Aug 2020, 06:03:06 EST Wed, 26 Aug 2020, 11:51:36 EST Wed, 26 Aug 2020, 11:54:18 EST Wed, 26 Aug 2020, 11:55:16 EST Wed, 26 Aug 2020, 11:56:20 EST Filtered Full Citation counts:   Cited 4 times in TR Web of Science Cited 3 times in Scopus Search Google Scholar Access Statistics: 17 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Thu, 20 Aug 2020, 13:02:11 EST

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