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Association between Maternal Iodine Intake in Pregnancy and Childhood Neurodevelopment at Age 18 Months

Zhou, Shao J., Condo, Dominique, Ryan, Philip, Skeaff, Sheila A., Howell, Stuart, Anderson, Peter J., McPhee, Andrew J. and Makrides, Maria 2019, Association between Maternal Iodine Intake in Pregnancy and Childhood Neurodevelopment at Age 18 Months, American Journal of Epidemiology, vol. 188, no. 2, pp. 332-338, doi: 10.1093/aje/kwy225.

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Title Association between Maternal Iodine Intake in Pregnancy and Childhood Neurodevelopment at Age 18 Months
Author(s) Zhou, Shao J.
Condo, DominiqueORCID iD for Condo, Dominique orcid.org/0000-0002-8348-7488
Ryan, Philip
Skeaff, Sheila A.
Howell, Stuart
Anderson, Peter J.
McPhee, Andrew J.
Makrides, Maria
Journal name American Journal of Epidemiology
Volume number 188
Issue number 2
Start page 332
End page 338
Total pages 7
Publisher Oxford Academic
Place of publication Oxford, Eng.
Publication date 2019-02
ISSN 0002-9262
1476-6256
Keyword(s) Bayley Scales
child development
iodine deficiency
iodine intake
pregnancy
urinary iodine concentration
Summary © The Author(s) 2018. There are limited and inconsistent data suggesting that mild iodine deficiency in pregnancy might be associated with poorer developmental outcomes in children. Between 2011 and 2015, we conducted a prospective cohort study in Australia examining the relationship between maternal iodine intake in pregnancy and childhood neurodevelopment, assessed using Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III), in 699 children at 18 months. Maternal iodine intake and urinary iodine concentration (UIC) were assessed at study entry (<20 weeks' gestation) and at 28 weeks' gestation. Maternal iodine intake in the lowest (<220 μg/day) or highest (≥391 μg/day) quartile was associated with lower cognitive, language, and motor scores (mean differences ranged from 2.4 (95% confidence interval (CI): 0.01, 4.8) to 7.0 (95% CI: 2.8, 11.1) points lower) and higher odds (odds ratios ranged from 2.7 (95% CI: 1.3, 5.6) to 2.8 (95% CI: 1.3, 5.7)) of cognitive developmental delay (Bayley-III score <85) compared with mothers with an iodine intake in the middle quartiles. There was no association between UIC in pregnancy and Bayley-III outcomes regardless of whether UIC and the outcomes were analyzed as continuous or categorical variables. Both low and high iodine intakes in pregnancy were associated with poorer childhood neurodevelopment in this iodine-sufficient population.
Language eng
DOI 10.1093/aje/kwy225
Indigenous content off
Field of Research 111704 Community Child Health
01 Mathematical Sciences
11 Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30140996

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.