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The global distribution of lymphatic filariasis, 2000–18: a geospatial analysis

Deshpande, A, Miller-Petrie, MK, Johnson, KB, Abdoli, A, Abrigo, MRM, Adekanmbi, V, Adetokunboh, OO, Adinarayanan, S, Ahmadpour, E, Ahmed, MB, Akalu, TY, Alanzi, TM, Alinia, C, Alipour, V, Amit, AML, Anber, NH, Ancuceanu, R, Andualem, Z, Ansari, F, Antonio, CAT, Anvari, D, Appiah, S, Arabloo, J, Arnold, BF, Ausloos, M, Ayanore, MA, Badirzadeh, A, Baig, AA, Banach, M, Baraki, AG, Bärnighausen, TW, Bayati, M, Bhattacharyya, K, Bhutta, ZA, Bijani, A, Bockarie, MJ, Bisanzio, D, Biswas, RK, Bohlouli, S, Cano, J, Carvalho, F, Chattu, VK, Chavshin, C, Cormier, NM, Cromwell, EA, Schmidt, CA, Kwong, KT, Damiani, G, Dandona, R, Dandona, L, Darwesh, AM, Daryani, A, Dash, AP, Deribe, K, Dessu, B, Dhimal, M, Dianatinasab, M, Diaz, D, Do, HT, Earl, L, El Tantawi, M, Faraj, A, Fattahi, N, Fernandes, E, Fischer, F, Foigt, NA, Foroutan, M, Guo, Y, Hailu, GB, Hasaballah, AI, Hassankhani, H, Hassankhani, H, Herteliu, C, de Hidru, HD, Hon, J, Hole, MK, Hossain, N, Hosseinzadeh, M, Househ, M, Humayun, A, Ilesanmi, OS, Ilic, MD, Iqbal, U, Irvani, SSN, Shariful Islam, Sheikh, Jha, RP, Ji, JS, Jozwiak, JJ, Kabir, A, Kalankesh, LR, Kalhor, R, Karami Matin, B, Karch, A, Karimi, S, Kasaeian, A, Kazemi Karyani, A, Kayode, GA, Kelbore, AG, Khafaie, MA and Khalilov, R 2020, The global distribution of lymphatic filariasis, 2000–18: a geospatial analysis, The Lancet Global Health, vol. 8, no. 9, pp. e1186-e1194, doi: 10.1016/S2214-109X(20)30286-2.

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Title The global distribution of lymphatic filariasis, 2000–18: a geospatial analysis
Author(s) Deshpande, A
Miller-Petrie, MK
Johnson, KB
Abdoli, A
Abrigo, MRM
Adekanmbi, V
Adetokunboh, OO
Adinarayanan, S
Ahmadpour, E
Ahmed, MB
Akalu, TY
Alanzi, TM
Alinia, C
Alipour, V
Amit, AML
Anber, NH
Ancuceanu, R
Andualem, Z
Ansari, F
Antonio, CAT
Anvari, D
Appiah, S
Arabloo, J
Arnold, BF
Ausloos, M
Ayanore, MA
Badirzadeh, A
Baig, AA
Banach, M
Baraki, AG
Bärnighausen, TW
Bayati, M
Bhattacharyya, K
Bhutta, ZA
Bijani, A
Bockarie, MJ
Bisanzio, D
Biswas, RK
Bohlouli, S
Cano, J
Carvalho, F
Chattu, VK
Chavshin, C
Cormier, NM
Cromwell, EA
Schmidt, CA
Kwong, KT
Damiani, G
Dandona, R
Dandona, L
Darwesh, AM
Daryani, A
Dash, AP
Deribe, K
Dessu, B
Dhimal, M
Dianatinasab, M
Diaz, D
Do, HT
Earl, L
El Tantawi, M
Faraj, A
Fattahi, N
Fernandes, E
Fischer, F
Foigt, NA
Foroutan, M
Guo, Y
Hailu, GB
Hasaballah, AI
Hassankhani, H
Hassankhani, H
Herteliu, C
de Hidru, HD
Hon, J
Hole, MK
Hossain, N
Hosseinzadeh, M
Househ, M
Humayun, A
Ilesanmi, OS
Ilic, MD
Iqbal, U
Irvani, SSN
Shariful Islam, SheikhORCID iD for Shariful Islam, Sheikh
Jha, RP
Ji, JS
Jozwiak, JJ
Kabir, A
Kalankesh, LR
Kalhor, R
Karami Matin, B
Karch, A
Karimi, S
Kasaeian, A
Kazemi Karyani, A
Kayode, GA
Kelbore, AG
Khafaie, MA
Khalilov, R
Journal name The Lancet Global Health
Volume number 8
Issue number 9
Start page e1186
End page e1194
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2020-09
ISSN 2214-109X
Keyword(s) Local Burden of Disease 2019 Neglected Tropical Diseases Collaborators
Summary Background: Lymphatic filariasis is a neglected tropical disease that can cause permanent disability through disruption of the lymphatic system. This disease is caused by parasitic filarial worms that are transmitted by mosquitos. Mass drug administration (MDA) of antihelmintics is recommended by WHO to eliminate lymphatic filariasis as a public health problem. This study aims to produce the first geospatial estimates of the global prevalence of lymphatic filariasis infection over time, to quantify progress towards elimination, and to identify geographical variation in distribution of infection. Methods: A global dataset of georeferenced surveyed locations was used to model annual 2000–18 lymphatic filariasis prevalence for 73 current or previously endemic countries. We applied Bayesian model-based geostatistics and time series methods to generate spatially continuous estimates of global all-age 2000–18 prevalence of lymphatic filariasis infection mapped at a resolution of 5 km2 and aggregated to estimate total number of individuals infected. Findings: We used 14 927 datapoints to fit the geospatial models. An estimated 199 million total individuals (95% uncertainty interval 174–234 million) worldwide were infected with lymphatic filariasis in 2000, with totals for WHO regions ranging from 3·1 million (1·6–5·7 million) in the region of the Americas to 107 million (91–134 million) in the South-East Asia region. By 2018, an estimated 51 million individuals (43–63 million) were infected. Broad declines in prevalence are observed globally, but focal areas in Africa and southeast Asia remain less likely to have attained infection prevalence thresholds proposed to achieve local elimination. Interpretation: Although the prevalence of lymphatic filariasis infection has declined since 2000, MDA is still necessary across large populations in Africa and Asia. Our mapped estimates can be used to identify areas where the probability of meeting infection thresholds is low, and when coupled with large uncertainty in the predictions, indicate additional data collection or intervention might be warranted before MDA programmes cease. Funding: Bill & Melinda Gates Foundation.
Language eng
DOI 10.1016/S2214-109X(20)30286-2
Indigenous content off
Field of Research 0605 Microbiology
1117 Public Health and Health Services
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2020, The Author(s)
Free to Read? Yes
Use Rights Creative Commons Attribution licence
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