Abnormal dose-response melatonin suppression by light in bipolar type i patients compared with healthy adult subjects

Hallam, Karen T, Begg, Denovan P, Olver, James S and Norman, Trevor R 2009, Abnormal dose-response melatonin suppression by light in bipolar type i patients compared with healthy adult subjects, Acta Neuropsychiatrica, vol. 21, no. 5, pp. 246-255, doi: 10.1111/j.1601-5215.2009.00416.x.

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Title Abnormal dose-response melatonin suppression by light in bipolar type i patients compared with healthy adult subjects
Author(s) Hallam, Karen TORCID iD for Hallam, Karen T orcid.org/0000-0003-0495-5341
Begg, Denovan P
Olver, James S
Norman, Trevor R
Journal name Acta Neuropsychiatrica
Volume number 21
Issue number 5
Start page 246
End page 255
Total pages 10
Publisher WILEY-BLACKWELL PUBLISHING, INC
Place of publication England
Publication date 2009-01-01
ISSN 0924-2708
1601-5215
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Neurosciences
Psychiatry
Neurosciences & Neurology
biological marker
bipolar disorder
dose response
light
melatonin
patients
AFFECTIVE-DISORDER
NOCTURNAL MELATONIN
RATING-SCALE
DEPRESSED-PATIENTS
AFFECTIVE-ILLNESS
MOOD DISORDERS
SWEDISH TWIN
DIM LIGHT
SENSITIVITY
UNIPOLAR
Summary Objective:Among potential endophenotypes proposed for bipolar affective disorder focusing on circadian abnormalities associated with the illness has particularly high face validity. Melatonin sensitivity to light is one circadian endophenotype proposed as useful in bipolar disorder. The aim of this study was to investigate melatonin sensitivity to light over a range of light intensities in order to compare and contrast responses in bipolar I patients with those of healthy adult volunteers.Methods:The study included seven patients (4 females, 3 males) with bipolar I disorder and 34 control participants (22 females, 12 males) with no personal or family history of affective illness. Melatonin sensitivity to light was determined in all patients and participants across a range of light intensities (0, 200, 500 and 1000 lux).Results:The results indicated that patients showed melatonin super-sensitivity to light in comparison with controls, a response that was consistent across the entire light intensity range investigated.Conclusion:The study provides further evidence for a super sensitive response in bipolar I patients and suggests that its potential usefulness as an endophenotypic marker of the illness is deserving of further research.
Language eng
DOI 10.1111/j.1601-5215.2009.00416.x
Indigenous content off
Field of Research 11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30141531

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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