Nano-sized solid dispersions for improving the bioavailability of poorly water-soluble drugs

Tran, Ha Lien Phuong and Tran, Thao T. D. 2020, Nano-sized solid dispersions for improving the bioavailability of poorly water-soluble drugs, Current Pharmaceutical Design, vol. 26, no. 38, pp. 4917-4924, doi: 10.2174/1381612826666200701134135.


Title Nano-sized solid dispersions for improving the bioavailability of poorly water-soluble drugs
Author(s) Tran, Ha Lien PhuongORCID iD for Tran, Ha Lien Phuong orcid.org/0000-0001-8463-7516
Tran, Thao T. D.
Journal name Current Pharmaceutical Design
Volume number 26
Issue number 38
Start page 4917
End page 4924
Total pages 8
Publisher Bentham Science Publishers
Place of publication Sharjah, United Arab Emirates
Publication date 2020-06-30
ISSN 1381-6128
1873-4286
Keyword(s) Solid dispersions
amorphous
bioavailability
dispersions
nano-sized
poorly water-soluble drugs
Summary It has been well established that solid dispersions have a high potential to increase the release rate of poorly water-soluble drugs, resulting in high drug bioavailability. Solid dispersions have been vigorously investigatedwith various practical approaches in recent decades. Improvements in wettability, molecular interactions and drugs being held in an amorphous state in solid dispersions are the main mechanisms underlying the highdrug release rate. Moreover, the synergistic effect of incorporating nanotechnology in solid dispersions is expected to lead to an advanced drug delivery system for poorly water-soluble drugs. However, to date, there is still a lack of reviews providing outlooks on the nano-sized solid dispersions that have been substantially investigated for improving the bioavailability of poorly water-soluble drugs. In the current review, we aim to overview key advantages and approaches for producing nano-sized solid dispersions. The classification of key strategies in developing nano-sized solid dispersions will advance the creation of even more efficient solid dispersions, which will translate into clinical studies.
Language eng
DOI 10.2174/1381612826666200701134135
Indigenous content off
Field of Research 1115 Pharmacology and Pharmaceutical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30141728

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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