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Molecular interactions in solid dispersions of poorly water-soluble drugs

Tran, Thao T. D. and Tran, Phuong H. L. 2020, Molecular interactions in solid dispersions of poorly water-soluble drugs, Pharmaceutics, vol. 12, no. 8, pp. 1-12, doi: 10.3390/pharmaceutics12080745.

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Title Molecular interactions in solid dispersions of poorly water-soluble drugs
Author(s) Tran, Thao T. D.
Tran, Phuong H. L.ORCID iD for Tran, Phuong H. L. orcid.org/0000-0001-8463-7516
Journal name Pharmaceutics
Volume number 12
Issue number 8
Start page 1
End page 12
Total pages 12
Publisher MDPI AG
Place of publication Basel, Switzerland
Publication date 2020-08-07
ISSN 1999-4923
1999-4923
Keyword(s) bonding force
bonding formation
molecular interaction
physicochemical characterization
poorly water-soluble drug
solid dispersion
Summary Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions. Typically, the detection of molecular interactions will assist in the explanation of different drug performances (e.g., dissolution, solubility, stability) in solid dispersions. Various prominent reviews on solid dispersions have been reported recently. However, there is still no overview of recent techniques for evaluating the molecular interactions that occur within solid dispersions of poorly water-soluble drugs. In this review, we aim to overview common methods that have been used for solid dispersions to identify different bond formations and forces via the determination of interaction energy. In addition, a brief background on the important role of molecular interactions will also be described. The summary and discussion of methods used in the determination of molecular interactions will contribute to further developments in solid dispersions, especially for quick and potent drug delivery applications.
Language eng
DOI 10.3390/pharmaceutics12080745
Indigenous content off
Field of Research 1115 Pharmacology and Pharmaceutical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30141733

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.