Openly accessible

Infection dynamics of Swine Influenza virus in a Danish pig herd reveals recurrent infections with different variants of the H1N2 Swine Influenza A virus subtype

Bhatta, Tarka Raj, Ryt-Hansen, Pia, Nielsen, Jens Peter, Larsen, Lars Erik, Larsen, Inge, Chamings, Anthony, Goecke, Nicole B. and Alexandersen, Soren 2020, Infection dynamics of Swine Influenza virus in a Danish pig herd reveals recurrent infections with different variants of the H1N2 Swine Influenza A virus subtype, Viruses, vol. 12, no. 9 - Special Issue : Evolution and Pathogenesis of Avian and Animal Influenza Viruses, doi: 10.3390/v12091013.

Attached Files
Name Description MIMEType Size Downloads

Title Infection dynamics of Swine Influenza virus in a Danish pig herd reveals recurrent infections with different variants of the H1N2 Swine Influenza A virus subtype
Author(s) Bhatta, Tarka RajORCID iD for Bhatta, Tarka Raj orcid.org/0000-0002-8199-8444
Ryt-Hansen, Pia
Nielsen, Jens Peter
Larsen, Lars Erik
Larsen, Inge
Chamings, AnthonyORCID iD for Chamings, Anthony orcid.org/0000-0002-7762-4757
Goecke, Nicole B.
Alexandersen, SorenORCID iD for Alexandersen, Soren orcid.org/0000-0002-5039-3178
Journal name Viruses
Volume number 12
Issue number 9 - Special Issue : Evolution and Pathogenesis of Avian and Animal Influenza Viruses
Article ID 1013
Total pages 18
Publisher MDPI AG
Place of publication Basel, Switzerland
Publication date 2020-09-10
ISSN 1999-4915
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Virology
swine influenza A virus (swIAV)
prevalence
antigenic diversity
phylogenetic analysis
pig herd
ANTIGENIC SITES
EUROPEAN SWINE
CELL EPITOPES
HEMAGGLUTININ
NEURAMINIDASE
EVOLUTION
ORIGIN
EPIDEMIOLOGY
PROTECTION
CYTOKINES
H1N2
Summary Influenza A virus (IAV) in swine, so-called swine influenza A virus (swIAV), causes respiratory illness in pigs around the globe. In Danish pig herds, a H1N2 subtype named H1N2dk is one of the main circulating swIAV. In this cohort study, the infection dynamic of swIAV was evaluated in a Danish pig herd by sampling and PCR testing of pigs from two weeks of age until slaughter at 22 weeks of age. In addition, next generation sequencing (NGS) was used to identify and characterize the complete genome of swIAV circulating in the herd, and to examine the antigenic variability in the antigenic sites of the virus hemagglutinin (HA) and neuraminidase (NA) proteins. Overall, 76.6% of the pigs became PCR positive for swIAV during the study, with the highest prevalence at four weeks of age. Detailed analysis of the virus sequences obtained showed that the majority of mutations occurred at antigenic sites in the HA and NA proteins of the virus. At least two different H1N2 variants were found to be circulating in the herd; one H1N2 variant was circulating at the sow and nursery sites, while another H1N2 variant was circulating at the finisher site. Furthermore, it was demonstrated that individual pigs had recurrent swIAV infections with the two different H1N2 variants, but re-infection with the same H1N2 variant was also observed. Better understandings of the epidemiology, genetic and antigenic diversity of swIAV may help to design better health interventions for the prevention and control of swIAV infections in the herds.
Language eng
DOI 10.3390/v12091013
Indigenous content off
Field of Research 0605 Microbiology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2020, The Authors
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30142389

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 17 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Mon, 21 Sep 2020, 15:15:48 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.