Heritability of overlapping impulsivity and compulsivity dimensional phenotypes Tiego, J, Chamberlain, SR, Harrison, BJ, Dawson, A, Albertella, L, Youssef, GJ, Fontenelle, LF and Yücel, M 2020, Heritability of overlapping impulsivity and compulsivity dimensional phenotypes, Scientific Reports, vol. 10, no. 1, pp. 1-17, doi: 10.1038/s41598-020-71013-x. Attached Files Name Description MIMEType Size Downloads youssef-heritabilityofoverlapping-2020.pdf Published version application/pdf 1.15MB 15 Title Heritability of overlapping impulsivity and compulsivity dimensional phenotypes Author(s) Tiego, J Chamberlain, SR Harrison, BJ Dawson, A Albertella, L Youssef, GJ orcid.org/0000-0002-6178-4895 Fontenelle, LF Yücel, M Journal name Scientific Reports Volume number 10 Issue number 1 Article ID 14378 Start page 1 End page 17 Total pages 17 Publisher Springer Science and Business Media LLC Place of publication Berlin, Germany Publication date 2020-09-01 ISSN 2045-2322 2045-2322 Keyword(s) Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics GENOME-WIDE ASSOCIATION ITEM RESPONSE THEORY BEHAVIORAL DISINHIBITION ENVIRONMENTAL-INFLUENCES PSYCHOMETRIC VALIDATION HIERARCHICAL TAXONOMY ENDOPHENOTYPE CONCEPT SPECTRUM DISORDERS MEASUREMENT ISSUES ANXIETY DISORDER Summary Impulsivity and compulsivity are traits relevant to a range of mental health problems and have traditionally been conceptualised as distinct constructs. Here, we reconceptualised impulsivity and compulsivity as partially overlapping phenotypes using a bifactor modelling approach and estimated heritability for their shared and unique phenotypic variance within a classical twin design. Adult twin pairs (N = 173) completed self-report questionnaires measuring psychological processes related to impulsivity and compulsivity. We fitted variance components models to three uncorrelated phenotypic dimensions: a general impulsive–compulsive dimension; and two narrower phenotypes related to impulsivity and obsessiveness.There was evidence of moderate heritability for impulsivity (A2 = 0.33), modest additive genetic or common environmental effects for obsessiveness (A2 = 0.25; C2 = 0.23), and moderate effects of common environment (C2 = 0.36) for the general dimension, This general impulsive–compulsive phenotype may reflect a quantitative liability to related mental health disorders that indexes exposure to potentially modifiable environmental risk factors. Language eng DOI 10.1038/s41598-020-71013-x Indigenous content off HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2020, The Author(s) Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30142408 Document type: Journal Article Collections: Faculty of Health School of Psychology Open Access Collection Related Links Link Description Link to full-text (open access)     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 21 Sep 2020, 15:23:46 EST Tue, 22 Sep 2020, 05:02:00 EST Sat, 24 Oct 2020, 01:30:21 EST Tue, 12 Jan 2021, 05:10:57 EST Mon, 08 Feb 2021, 09:36:35 EST Mon, 08 Feb 2021, 09:38:09 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 20 Abstract Views, 15 File Downloads  -  Detailed Statistics Created: Mon, 21 Sep 2020, 15:23:46 EST

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