Effect of prepubertal gonadectomy and sex steroid treatment on the growth and lymphocyte populations of the rat thymus

Windmill, Kelly F, Meade, BJ and Lee, VWK 1993, Effect of prepubertal gonadectomy and sex steroid treatment on the growth and lymphocyte populations of the rat thymus, Reproduction, Fertility and Development, vol. 5, no. 1, pp. 73-81, doi: 10.1071/RD9930073.

Attached Files
Name Description MIMEType Size Downloads

Title Effect of prepubertal gonadectomy and sex steroid treatment on the growth and lymphocyte populations of the rat thymus
Author(s) Windmill, Kelly F
Meade, BJ
Lee, VWK
Journal name Reproduction, Fertility and Development
Volume number 5
Issue number 1
Start page 73
End page 81
Total pages 9
Publisher CSIRO Publishing
Place of publication Australia
Publication date 1993-01-01
ISSN 1031-3613
1448-5990
Summary The age at which rats are most sensitive to prepubertal gonadectomy, in terms of thymic growth, was investigated. Gonadectomy enhanced thymic growth at each age; the greatest difference in thymic weight between gonadectomized and intact animals occurred in male rats gonadectomized at 5 weeks of age (64%) and in female rats gonadectomized at 4-5 weeks of age (43-46%). The effect of various synthetic sex steroids on growth and lymphocyte populations of the thymus in gonadectomized rats was examined. Diethylstilboestrol, 1 mg per animal, inhibited thymic growth by more than 35% in both males and females. Ethinyloestradiol, 40 micrograms per animal, inhibited thymic growth by 26% in males but by only 4% in females. Fluoxymesterone, 10 mg per animal, inhibited thymic growth by more than 46% in both sexes. Norgestrel, 12 micrograms per animal, had no effect on thymic growth. The synthetic steroids that significantly inhibited thymic growth decreased the intensity and altered the localization of staining for total T cells (antibody clone MRC OX 19), T helper cells and macrophages (W 3/5), T cytotoxic/suppressor cells (MRC OX 8) and B cells (MRC OX 12).
Language eng
DOI 10.1071/RD9930073
Indigenous content off
Field of Research 06 Biological Sciences
07 Agricultural and Veterinary Sciences
11 Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30142431

Document type: Journal Article
Collection: Office of the Deputy Vice-Chancellor (Research)
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 38 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 36 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Mon, 21 Sep 2020, 15:31:21 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.