Mediterranean Diet and Telomere Length: A Systematic Review and Meta-Analysis

Canudas, Silvia, Becerra-Tomás, Nerea, Hernández-Alonso, Pablo, Galié, Serena, Leung, Cindy, Crous-Bou, Marta, De Vivo, Immaculata, Gao, Yawen, Gu, Yian, Meinilä, Jelena, Milte, Catherine, García-Calzón, Sonia, Marti, Amelia, Boccardi, Virginia, Ventura-Marra, Melissa and Salas-Salvadó, Jordi 2020, Mediterranean Diet and Telomere Length: A Systematic Review and Meta-Analysis, Advances in Nutrition, vol. 11, no. 6, pp. 1544-1554, doi: 10.1093/advances/nmaa079.

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Title Mediterranean Diet and Telomere Length: A Systematic Review and Meta-Analysis
Author(s) Canudas, Silvia
Becerra-Tomás, Nerea
Hernández-Alonso, Pablo
Galié, Serena
Leung, Cindy
Crous-Bou, Marta
De Vivo, Immaculata
Gao, Yawen
Gu, Yian
Meinilä, Jelena
Milte, CatherineORCID iD for Milte, Catherine
García-Calzón, Sonia
Marti, Amelia
Boccardi, Virginia
Ventura-Marra, Melissa
Salas-Salvadó, Jordi
Journal name Advances in Nutrition
Volume number 11
Issue number 6
Start page 1544
End page 1554
Total pages 11
Publisher Oxford University Press (OUP)
Place of publication Oxford, Eng.
Publication date 2020-11-16
ISSN 2156-5376
Keyword(s) Mediterranean diet
accelerated telomere shortening
age-associated diseases
dietary pattern
healthy aging
telomere length
Summary Accelerated telomere shortening has been associated with several age-related diseases and/or decreased lifespan in humans. The Mediterranean diet (MedDiet) is considered to be 1 of the most recognized diets for disease prevention and healthy aging, partially due to its demonstrated anti-inflammatory and antioxidative properties which may impact on telomere length (TL). The aim of this meta-analysis was to determine the associations between MedDiet adherence and TL maintenance. MEDLINE-PubMed and Cochrane databases were searched up to December 2018 for studies evaluating the association between MedDiet adherence and TL in blood cells. Two reviewers, working independently, screened all titles and abstracts to identify studies that met the inclusion criteria [cross-sectional, case-control, and prospective cohort studies and randomized clinical trials (RCTs) published in English and excluded nonoriginal articles]. Data were pooled by the generic inverse variance method using the random effects model and expressed as standardized mean difference (SMD). Heterogeneity was identified using the Cochran Q test and quantified by the I2 statistic. A total of 8 original cross-sectional studies were included for the quantitative meta-analysis, comprising a total of 13,733 participants from 5 countries. A positive association between adherence to the MedDiet and TL was observed in all meta-analyses, with the exception of those conducted only in men: SMD (95% CI) of 0.130 (0.029; 0.231) for all subjects, 0.078 (0.005; 0.152) for women, and 0.095 (–0.005; 0.195) for men. Only 1 prospective cohort study and 1 RCT were identified, therefore, we could not undertake a meta-analysis for these study designs. The present meta-analysis of cross-sectional studies demonstrates that higher MedDiet adherence is associated with longer TL. At the same time, larger and high-quality prospective studies and clinical trials are warranted to confirm this association.
Language eng
DOI 10.1093/advances/nmaa079
Indigenous content off
Field of Research 1111 Nutrition and Dietetics
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2020, The Authors
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Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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