Total Antioxidant Capacity and Frailty in Older Men Tembo, Monica Chimwemwe, Holloway-Kew, KL, Bortolasci, Chiara, Sui, Sophia, Brennan-Olsen, Sharon, Williams, Lana, Kotowicz, Mark and Pasco, Julie 2020, Total Antioxidant Capacity and Frailty in Older Men, American Journal of Men's Health, September - October, pp. 1-6, doi: 10.1177/1557988320946592. Attached Files Name Description MIMEType Size Downloads Title Total Antioxidant Capacity and Frailty in Older Men Author(s) Tembo, Monica Chimwemwe orcid.org/0000-0003-1210-2437 Holloway-Kew, KL Bortolasci, Chiara orcid.org/0000-0002-0794-6363 Sui, Sophia orcid.org/0000-0001-6388-1261 Brennan-Olsen, Sharon orcid.org/0000-0003-3269-5401 Williams, Lana orcid.org/0000-0002-1377-1272 Kotowicz, Mark orcid.org/0000-0002-8094-1411 Pasco, Julie orcid.org/0000-0002-8968-4714 Journal name American Journal of Men's Health Season September - October Start page 1 End page 6 Total pages 6 Publisher Sage Place of publication London, Eng. Publication date 2020 ISSN 1557-9883 1557-9891 Keyword(s) Science & Technology Life Sciences & Biomedicine Endocrinology & Metabolism Public, Environmental & Occupational Health Total antioxidant capacity frailty oxidative stress Summary Frailty, a clinical syndrome characterized by multisystem dysregulation, has been associated with high levels of oxidative stress. We investigated the association between serum total antioxidant capacity (TAC) and frailty in older men. This cross-sectional study included 581 men (age 60–90 years) enrolled in the Geelong Osteoporosis Study. Frailty comprised at least three of unintentional weight loss, exhaustion, low physical activity, slowness, and weakness. Serum TAC was measured by quantitative colorimetric determination and expressed as uric acid equivalents (mM). Relationships between TAC (in SD units) and frailty were explored using multivariable logistic regression models. Sociodemographic, anthropometric, and lifestyle variables were tested as potential confounders and effect modifiers. A sensitivity analysis excluded participants ( n = 145) in the upper quartile of TAC, who were likely to have hyperuricemia. Fifty (8.6%) men were frail. There was evidence that higher TAC levels were associated with increased likelihood of frailty ( OR 1.34, 95% confidence interval [CI; 0.99, 1.80]), and this was attenuated after adjustment for age and body mass index (BMI; OR 1.26, 95% CI [0.93,1.71]). No effect modifiers or other confounders were identified. The sensitivity analysis revealed a positive association between TAC and frailty, before and after accounting for age and BMI (adjusted OR 1.79, 95% CI [1.01, 3.17] p = .038). These results suggest a positive association between TAC levels and frailty, supporting the hypothesis that this biomarker could be useful in identifying individuals at risk of frailty. We speculate that a milieu of heightened oxidative stress in frailty may elevate the oxidative stress regulatory set point, raising antioxidant activity. This warrants further investigation. Language eng DOI 10.1177/1557988320946592 Indigenous content off Field of Research 1117 Public Health and Health Services HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30143259 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Fri, 25 Sep 2020, 12:57:03 EST Sat, 26 Sep 2020, 05:00:41 EST Mon, 28 Sep 2020, 08:04:52 EST Tue, 12 Jan 2021, 05:08:22 EST Thu, 21 Jan 2021, 14:55:54 EST Thu, 21 Jan 2021, 14:57:05 EST Thu, 21 Jan 2021, 15:09:30 EST Sat, 23 Jan 2021, 01:30:03 EST Thu, 04 Feb 2021, 17:36:16 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 1 times in Scopus Search Google Scholar Access Statistics: 23 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Fri, 25 Sep 2020, 12:57:03 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.