Silk and wool protein micro-particle reinforced crystalline polylactic acid bio-composites with improved cell interaction for targeted biomedical applications Bhagabati, Purabi, Bhasney, Siddharth Mohan, Bose, Devleena, Remadevi, Remadevi, Setty, Mohan, Rajkhowa, Rangam and Katiyar, Vimal 2020, Silk and wool protein micro-particle reinforced crystalline polylactic acid bio-composites with improved cell interaction for targeted biomedical applications, ACS Applied Polymer Materials, vol. 2, no. 11, pp. 4739-4751, doi: 10.1021/acsapm.0c00673. Attached Files Name Description MIMEType Size Downloads Title Silk and wool protein micro-particle reinforced crystalline polylactic acid bio-composites with improved cell interaction for targeted biomedical applications Author(s) Bhagabati, Purabi Bhasney, Siddharth Mohan Bose, Devleena Remadevi, Remadevi Setty, Mohan orcid.org/0000-0003-1871-0249 Rajkhowa, Rangam orcid.org/0000-0002-6811-9126 Katiyar, Vimal Journal name ACS Applied Polymer Materials Volume number 2 Issue number 11 Start page 4739 End page 4751 Total pages 13 Publisher American Chemical Society (ACS) Place of publication Washington, D.C. Publication date 2020-11-13 Keyword(s) silk wool poly (lactic acid) bio-composite crystallization biocompatibility Summary Silk fibroin and wool keratin are easily available biocompatible structural protein fibers with cell adhesion properties. Bottom-up approaches to convert silk and wool fibers to biomaterials of different forms require harsh chemicals and result in materials with poor mechanical properties. In this work, microparticles were prepared from wool and three types of silk fibers by a top-down approach, which is scalable and requires less processing as compared to other bottom up approaches. The fabricated microparticles (5 wt %) were added during melt extrusion of poly(lactic acid) [PLA] to create hybrid biocomposites. Thermal stability of these protein particles in retaining the native structure present in fibers, particularly in silk varieties containing poly-alanine [poly(Ala)] domains, allowed their inclusion in melt-based processing without thermal degradation. The influence of protein microparticles of different amino acid compositions of silk and wool on molecular weight, crystal growth, microstructure, and mechanical, thermal, hydrophilic, and cell compatibility of PLA was investigated. Crystal density of PLA was increased up to 4.5 times and % crystallinity was increased up to 2 times on the addition of the particle fillers. Silk-containing amino acid repeats of poly(Ala) domains were found to be more effective fillers and had good interfacial adhesion with PLA, while the interaction between PLA and wool was poor. Silk fillers produced more hydrophilic biocomposites and supported higher activity of UMR 106 cells in comparison to neat PLA. PLA is gaining increasing attention from the research community and the biomedical industries as a potential alternate to metal implants in bone fixation devices. The study demonstrates that silk particles, particularly those with a poly(Ala) sequence, amplify the acceptability of PLA biocomposites as advanced biodegradable composites for targeted biomedical applications such as bone-fixation devices. Language eng DOI 10.1021/acsapm.0c00673 Indigenous content off Field of Research 090301 Biomaterials 091209 Polymers and Plastics HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Grant ID Australian Academy of Science through Australia India Strategic Research Fund Australian Research Council Future Fiber Hub Centre of Excellence for Sustainable polymers (CoE-Suspol) funded by the Department of Chemicals and Petrochemicals, Ministry of Chemicals and Fertilizers, Government of India Copyright notice ©2020, American Chemical Society Persistent URL http://hdl.handle.net/10536/DRO/DU:30143330 Document type: Journal Article Collections: Institute for Frontier Materials GTP Research Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 30 Sep 2020, 08:09:40 EST Thu, 01 Oct 2020, 05:00:29 EST Thu, 01 Oct 2020, 06:03:54 EST Thu, 01 Oct 2020, 08:52:50 EST Tue, 08 Dec 2020, 05:03:50 EST Tue, 15 Dec 2020, 13:12:06 EST Tue, 15 Dec 2020, 13:16:23 EST Tue, 15 Dec 2020, 15:04:24 EST Sat, 26 Dec 2020, 01:30:42 EST Sat, 09 Jan 2021, 01:39:53 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 11 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Wed, 30 Sep 2020, 08:09:40 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.