Alterations in corticospinal excitability with imposed vs. voluntary fatigue in human hand muscles

Pitcher, Julia B and Miles, Timothy S 2002, Alterations in corticospinal excitability with imposed vs. voluntary fatigue in human hand muscles, Journal of Applied Physiology, vol. 92, no. 5, pp. 2131-2138, doi: 10.1152/japplphysiol.00835.2001.

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Title Alterations in corticospinal excitability with imposed vs. voluntary fatigue in human hand muscles
Author(s) Pitcher, Julia BORCID iD for Pitcher, Julia B
Miles, Timothy S
Journal name Journal of Applied Physiology
Volume number 92
Issue number 5
Start page 2131
End page 2138
Total pages 8
Publisher American Physiological Society
Place of publication United States
Publication date 2002-05-01
ISSN 8750-7587
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Sport Sciences
transcranial magnetic stimulation
motor cortex
motor-evoked potential
Summary We aimed to determine whether postexercise depression of motor-evoked potentials (MEPs) could be demonstrated without voluntary muscle activation in humans. Voluntary fatigue was induced with a 2-min maximal voluntary contraction (MVC) of the first dorsal interosseous (FDI) muscle. On another occasion, “electrical fatigue” was induced with trains of shocks delivered for 2 min over the FDI motor point. Five of the twelve subjects also underwent “sequential fatigue” consisting of a 2-min MVC of FDI followed by 20 min of rest and then 2 min of motor point stimulation. Voluntary fatigue induced MEP depression that persisted for at least 20 min. Electrical fatigue induced a transient MEP facilitation that subsided 20 min after the stimulation and became depressed within 30 min. Thus MEP depression can be induced by both voluntary and electrical fatigue. With electrical fatigue, the initial depression is “masked” by transient MEP facilitation, reflecting cortical plasticity induced by the prolonged electrical stimulation. MEP depression probably reflects tonic afferent input from the exercising muscle that alters cortical excitability without altering spinal excitability.
Language eng
DOI 10.1152/japplphysiol.00835.2001
Indigenous content off
Field of Research 06 Biological Sciences
11 Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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