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Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches

Soto-Angona, Ó, Anmella, G, Valdés-Florido, MJ, De Uribe-Viloria, N, Carvalho, AF, Penninx, BWJH and Berk, Michael 2020, Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches, BMC Medicine, vol. 18, no. 1, pp. 1-14, doi: 10.1186/s12916-020-01713-8.

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Title Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches
Author(s) Soto-Angona, Ó
Anmella, G
Valdés-Florido, MJ
De Uribe-Viloria, N
Carvalho, AF
Penninx, BWJH
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name BMC Medicine
Volume number 18
Issue number 1
Article ID 261
Start page 1
End page 14
Total pages 14
Publisher BMC
Place of publication London, Eng.
Publication date 2020-10-01
ISSN 1741-7015
Keyword(s) Inflammation
Lifestyle
Mental disorders
Metabolic syndrome
Mitochondrial
Non-alcoholic fatty liver disease
Non-alcoholic steatohepatitis
Non-communicable disorders
Oxidative stress
Psychiatry
Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
BIPOLAR DISORDER
MENTAL-DISORDERS
RISK-FACTORS
HISTOLOGICAL SEVERITY
GLOBAL EPIDEMIOLOGY
PSYCHOTIC DISORDERS
GENDER-DIFFERENCES
PHYSICAL-ACTIVITY
GUT-MICROBIOTA
Summary Background: Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in over 5% of the parenchyma in the absence of excessive alcohol consumption. It is more prevalent in patients with diverse mental disorders, being part of the comorbidity driving loss of life expectancy and quality of life, yet remains a neglected entity. NAFLD can progress to non-alcoholic steatohepatitis (NASH) and increases the risk for cirrhosis and hepatic carcinoma. Both NAFLD and mental disorders share pathophysiological pathways, and also present a complex, bidirectional relationship with the metabolic syndrome (MetS) and related cardiometabolic diseases. Main text: This review compares the demographic data on NAFLD and NASH among the global population and the psychiatric population, finding differences that suggest a higher incidence of this disease among the latter. It also analyzes the link between NAFLD and psychiatric disorders, looking into common pathophysiological pathways, such as metabolic, genetic, and lifestyle factors. Finally, possible treatments, tailored approaches, and future research directions are suggested. Conclusion: NAFLD is part of a complex system of mental and non-communicable somatic disorders with a common pathogenesis, based on shared lifestyle and environmental risks, mediated by dysregulation of inflammation, oxidative stress pathways, and mitochondrial function. The recognition of the prevalent comorbidity between NAFLD and mental disorders is required to inform clinical practice and develop novel interventions to prevent and treat these complex and interacting disorders.
Language eng
DOI 10.1186/s12916-020-01713-8
Indigenous content off
Field of Research 11 Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2020, The Author(s)
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30143766

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.