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An internet-based intervention augmented with a diet and physical activity consultation to decrease the risk of dementia in at-risk adults in a primary care setting: pragmatic randomized controlled trial

Anstey, Kaarin J, Cherbuin, Nicolas, Kim, Sarang, McMaster, Mitchell, D'Este, Catherine, Lautenschlager, Nicola, Rebok, George, McRae, Ian, Torres, Susan J, Cox, Kay L and Pond, Constance D 2020, An internet-based intervention augmented with a diet and physical activity consultation to decrease the risk of dementia in at-risk adults in a primary care setting: pragmatic randomized controlled trial, Journal of medical Internet research, vol. 22, no. 9, pp. 1-15, doi: 10.2196/19431.

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Title An internet-based intervention augmented with a diet and physical activity consultation to decrease the risk of dementia in at-risk adults in a primary care setting: pragmatic randomized controlled trial
Author(s) Anstey, Kaarin J
Cherbuin, Nicolas
Kim, Sarang
McMaster, Mitchell
D'Este, Catherine
Lautenschlager, Nicola
Rebok, George
McRae, Ian
Torres, Susan JORCID iD for Torres, Susan J orcid.org/0000-0002-2599-1934
Cox, Kay L
Pond, Constance D
Journal name Journal of medical Internet research
Volume number 22
Issue number 9
Article ID e19431
Start page 1
End page 15
Total pages 15
Publisher JMIR Publications
Place of publication Toronto, Ont.
Publication date 2020-09
ISSN 1438-8871
1438-8871
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Health Care Sciences & Services
Medical Informatics
risk reduction behavior
dementia prevention & control
primary prevention
pragmatic clinical trial
prevention
primary care
Summary Background There is a need to develop interventions to reduce the risk of dementia in the community by addressing lifestyle factors and chronic diseases over the adult life course. Objective This study aims to evaluate a multidomain dementia risk reduction intervention, Body Brain Life in General Practice (BBL-GP), targeting at-risk adults in primary care. Methods A pragmatic, parallel, three-arm randomized trial involving 125 adults aged 18 years or older (86/125, 68.8% female) with a BMI of ≥25 kg/m2 or a chronic health condition recruited from general practices was conducted. The arms included (1) BBL-GP, a web-based intervention augmented with an in-person diet and physical activity consultation; (2) a single clinician–led group, Lifestyle Modification Program (LMP); and (3) a web-based control. The primary outcome was the Australian National University Alzheimer Disease Risk Index Short Form (ANU-ADRI-SF). Results Baseline assessments were conducted on 128 participants. A total of 125 participants were randomized to 3 groups (BBL-GP=42, LMP=41, and control=42). At immediate, week 18, week 36, and week 62 follow-ups, the completion rates were 43% (18/42), 57% (24/42), 48% (20/42), and 48% (20/42), respectively, for the BBL-GP group; 71% (29/41), 68% (28/41), 68% (28/41), and 51% (21/41), respectively, for the LMP group; and 62% (26/42), 69% (29/42), 60% (25/42), and 60% (25/42), respectively, for the control group. The primary outcome of the ANU-ADRI-SF score was lower for the BBL-GP group than the control group at all follow-ups. These comparisons were all significant at the 5% level for estimates adjusted for baseline differences (immediate: difference in means −3.86, 95% CI −6.81 to −0.90, P=.01; week 18: difference in means −4.05, 95% CI −6.81 to −1.28, P<.001; week 36: difference in means −4.99, 95% CI −8.04 to −1.94, P<.001; and week 62: difference in means −4.62, 95% CI −7.62 to −1.62, P<.001). Conclusions A web-based multidomain dementia risk reduction program augmented with allied health consultations administered within the general practice context can reduce dementia risk exposure for at least 15 months. This study was limited by a small sample size, and replication on a larger sample with longer follow-up will strengthen the results. Trial Registration Australian clinical trials registration number (ACTRN): 12616000868482; https://anzctr.org.au/ACTRN12616000868482.aspx.
Language eng
DOI 10.2196/19431
Indigenous content off
Field of Research 08 Information and Computing Sciences
11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30143802

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.