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Risk Factors for Incidence of Cardiovascular Diseases and All-Cause Mortality in a Middle Eastern Population over a Decade Follow-up: Tehran Lipid and Glucose Study

Sardarinia, M, Akbarpour, S, Lotfaliany, M, Bagherzadeh-Khiabani, F, Bozorgmanesh, M, Sheikholeslami, F, Azizi, F and Hadaegh, F 2016, Risk Factors for Incidence of Cardiovascular Diseases and All-Cause Mortality in a Middle Eastern Population over a Decade Follow-up: Tehran Lipid and Glucose Study, PloS one, vol. 11, no. 12, pp. 1-16, doi: 10.1371/journal.pone.0167623.

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Title Risk Factors for Incidence of Cardiovascular Diseases and All-Cause Mortality in a Middle Eastern Population over a Decade Follow-up: Tehran Lipid and Glucose Study
Author(s) Sardarinia, M
Akbarpour, S
Lotfaliany, MORCID iD for Lotfaliany, M orcid.org/0000-0001-6594-9004
Bagherzadeh-Khiabani, F
Bozorgmanesh, M
Sheikholeslami, F
Azizi, F
Hadaegh, F
Journal name PloS one
Volume number 11
Issue number 12
Article ID e0167623
Start page 1
End page 16
Total pages 16
Publisher PLOS
Place of publication San Francisco, CA
Publication date 2016
ISSN 1932-6203
Keyword(s) Cardiovascular diseases
Cardiovascular disease risk
Obesity
Cancer risk factors
Diabetes mellitus
Body mass index
Chronic kidney disease
Hypertension
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
BODY-MASS INDEX
CHRONIC KIDNEY-DISEASE
WAIST CIRCUMFERENCE
MYOCARDIAL-INFARCTION
DIABETES-MELLITUS
OBESITY PARADOX
POOLED ANALYSIS
52 COUNTRIES
PREVALENCE
Summary Background: To examine the association between potentially modifiable risk factors with cardiovascular disease (CVD) and all-cause mortality and to quantify their population attributable fractions (PAFs) among a sample of Tehran residents.Methods: Overall, 8108 participants (3686 men) aged≥30 years, were investigated. To examine the association between risk factors and outcomes, multivariate sex-adjusted Cox proportional hazard regression analysis were conducted, using age as time-scale in two models including general/central adiposity: 1)adjusted for different independent variables including smoking, education, family history of CVD and sex for both outcomes and additionally adjusted for prevalent CVD for all-cause mortality 2)further adjusted for obesity mediators (hypertension, diabetes, lipid profile and chronic kidney disease). Separate models were used including either general or central adiposity.Results: During median follow-up of >10 years, 827 first CVD events and 551 deaths occurred. Both being overweight (hazard ratio (HR), 95%CI: 1.41, 1.18–1.66, PAF 13.66) and obese (1.51, 1.24–1.84, PAF 9.79) played significant roles for incident CVD in the absence of obesity mediators. Predicting CVD, in the presence of general adiposity and its mediators, significant positive associations were found for hypercholesterolemia (1.59, 1.36–1.85, PAF 16.69), low HDL-C (1.21, 1.03–1.41, PAF 12.32), diabetes (1.86, 1.57–2.27, PAF 13.87), hypertension (1.79, 1.46–2.19, PAF 21.62) and current smoking (1.61, 1.34–1.94, PAF 7.57). Central adiposity remained a significant positive predictor, even after controlling for mediators (1.17, 1.01–1.35, PAF 7.55). For all-cause mortality, general/central obesity did not have any risk even in the absence of obesity mediators. Predictors including diabetes (2.56, 2.08–3.16, PAF 24.37), hypertension (1.43, 1.11–1.84, PAF 17.13), current smoking (1.75, 1.38–2.22, PAF 7.71), and low education level (1.59, 1.01–2.51, PAF 27.08) were associated with higher risk, however, hypertriglyceridemia (0.83, 0.68–1.01) and being overweight (0.71, 0.58–0.87) were associated with lower risk.Conclusions: Modifiable risk factors account for more than 70% risk for both CVD and mortality events.
Language eng
DOI 10.1371/journal.pone.0167623
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2016, Sardarinia et al.
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30144089

Document type: Journal Article
Collections: Faculty of Health
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.