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Impact of hypertension versus diabetes on cardiovascular and all-cause mortality in Iranian older adults: Results of 14 years of follow-up

Zafari, N, Asgari, S, Lotfaliany, M, Hadaegh, A, Azizi, F and Hadaegh, F 2017, Impact of hypertension versus diabetes on cardiovascular and all-cause mortality in Iranian older adults: Results of 14 years of follow-up, Scientific Reports, vol. 7, no. 1, pp. 1-8, doi: 10.1038/s41598-017-14631-2.

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Title Impact of hypertension versus diabetes on cardiovascular and all-cause mortality in Iranian older adults: Results of 14 years of follow-up
Author(s) Zafari, N
Asgari, S
Lotfaliany, MORCID iD for Lotfaliany, M orcid.org/0000-0001-6594-9004
Hadaegh, A
Azizi, F
Hadaegh, F
Journal name Scientific Reports
Volume number 7
Issue number 1
Article ID 14220
Start page 1
End page 8
Total pages 8
Publisher Nature Research
Place of publication Berlin, Germany
Publication date 2017-10-27
ISSN 2045-2322
Keyword(s) Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
SYSTOLIC BLOOD-PRESSURE
RISK-FACTORS
HEART-DISEASE
NONCOMMUNICABLE DISEASES
NATIONAL-SURVEY
GLOBAL BURDEN
POPULATION
COHORT
PREVALENCE
GLUCOSE
Summary To evaluate the joint effect of hypertension (HTN) and diabetes (DM) on coronary heart disease (CHD), and stroke event, all-cause, and cardiovascular disease (CVD) mortality in Middle Eastern older adults, 2747 people (1436 women) aged ≥ 50 years, free of CVD at baseline, were categorized into four groups (HTN−/DM−, HTN+/DM−, HTN−/DM+, HTN+/DM+). Multivariate Cox proportional hazard models were run for different outcomes. To compare the impact of HTN versus DM, HTN+/DM− was considered as reference. In a median of 13.9 years, incidence rate of CHD, and stroke event, all-cause and CVD mortality in total population were 19.0, 4.7, 13.5, and 6.4 per 1000 person-years, respectively. The multivariate sex-adjusted hazard ratios (HRs) of HTN−/DM+ for CHD, stroke, all-cause mortality and CVD mortality were 1.19 (confidence interval (CI): 0.9–1.57), 1.07 (CI: 0.63–1.82), 1.62 (CI: 1.2–2.18), and 1.28 (CI: 0.83–1.97); the corresponding HRs for HTN+/DM+ were 1.96 (CI: 1.57–2.46), 1.66 (CI: 1.1–2.52), 2.32 (CI: 1.8–2.98), and 2.6 (CI: 1.85–3.65) respectively. The associations between HTN/DM status with stroke incidence and all-cause mortality were stronger among men than in women (P for interaction <0.05). Compared to HTN+/DM−, HTN−/DM+ increases all-cause mortality by 62%, however, they are not considerably different regarding CHD, stroke incidence and CVD mortality.
Language eng
DOI 10.1038/s41598-017-14631-2
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2017, The Author(s)
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30144090

Document type: Journal Article
Collections: Faculty of Health
Open Access Collection
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