The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: Methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease

Ellis, KA, Bush, AI, Darby, D, De Fazio, D, Foster, J, Hudson, P, Lautenschlager, NT, Lenzo, N, Martins, RN, Maruff, P, Masters, C, Milner, A, Pike, K, Rowe, C, Savage, G, Szoeke, C, Taddei, K, Villemagne, V, Woodward, M and Gupta, Veer 2009, The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: Methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease, International Psychogeriatrics, vol. 21, no. 4, pp. 672-687, doi: 10.1017/S1041610209009405.

Attached Files
Name Description MIMEType Size Downloads

Title The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: Methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease
Author(s) Ellis, KA
Bush, AI
Darby, D
De Fazio, D
Foster, J
Hudson, P
Lautenschlager, NT
Lenzo, N
Martins, RN
Maruff, P
Masters, C
Milner, A
Pike, K
Rowe, C
Savage, G
Szoeke, C
Taddei, K
Villemagne, V
Woodward, M
Gupta, Veer
Journal name International Psychogeriatrics
Volume number 21
Issue number 4
Start page 672
End page 687
Total pages 16
Publisher Cambridge University Press (CUP)
Place of publication England
Publication date 2009-01-01
ISSN 1041-6102
1741-203X
Keyword(s) AIBL Research Group
Summary ABSTRACTBackground: The Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study of aging aimed to recruit 1000 individuals aged over 60 to assist with prospective research into Alzheimer's disease (AD). This paper describes the recruitment of the cohort and gives information about the study methodology, baseline demography, diagnoses, medical comorbidities, medication use, and cognitive function of the participants.Methods: Volunteers underwent a screening interview, had comprehensive cognitive testing, gave 80 ml of blood, and completed health and lifestyle questionnaires. One quarter of the sample also underwent amyloid PET brain imaging with Pittsburgh compound B (PiB PET) and MRI brain imaging, and a subgroup of 10% had ActiGraph activity monitoring and body composition scanning.Results: A total of 1166 volunteers were recruited, 54 of whom were excluded from further study due to comorbid disorders which could affect cognition or because of withdrawal of consent. Participants with AD (211) had neuropsychological profiles which were consistent with AD, and were more impaired than participants with mild cognitive impairment (133) or healthy controls (768), who performed within expected norms for age on neuropsychological testing. PiB PET scans were performed on 287 participants, 100 had DEXA scans and 91 participated in ActiGraph monitoring.Conclusion: The participants comprising the AIBL cohort represent a group of highly motivated and well-characterized individuals who represent a unique resource for the study of AD. They will be reassessed at 18-month intervals in order to determine the predictive utility of various biomarkers, cognitive parameters and lifestyle factors as indicators of AD, and as predictors of future cognitive decline.
Language eng
DOI 10.1017/S1041610209009405
Indigenous content off
Field of Research 11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30144657

Document type: Journal Article
Collections: Faculty of Health
Rural Clinical Schools
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 377 times in TR Web of Science
Scopus Citation Count Cited 397 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 63 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Thu, 29 Oct 2020, 07:35:33 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.