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Skeletal muscle microvascular perfusion responses to cuff occlusion and submaximal exercise assessed by contrast-enhanced ultrasound: The effect of age

Meneses, AL, Nam, MCY, Bailey, TG, Anstey, C, Golledge, J, Keske, MA, Greaves, K and Askew, CD 2020, Skeletal muscle microvascular perfusion responses to cuff occlusion and submaximal exercise assessed by contrast-enhanced ultrasound: The effect of age, Physiological Reports, vol. 8, no. 19, pp. 1-13, doi: 10.14814/phy2.14580.

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Title Skeletal muscle microvascular perfusion responses to cuff occlusion and submaximal exercise assessed by contrast-enhanced ultrasound: The effect of age
Author(s) Meneses, AL
Nam, MCY
Bailey, TG
Anstey, C
Golledge, J
Keske, MAORCID iD for Keske, MA orcid.org/0000-0003-4214-7628
Greaves, K
Askew, CD
Journal name Physiological Reports
Volume number 8
Issue number 19
Article ID e14580
Start page 1
End page 13
Total pages 13
Publisher Wiley
Place of publication Hoboken, NJ
Publication date 2020-10
ISSN 2051-817X
2051-817X
Keyword(s) aging
blood flow
exercise
muscle perfusion
reactive hyperemia
vascular conductance
Science & Technology
Life Sciences & Biomedicine
Physiology
FLOW-MEDIATED DILATION
CHRONIC HEART-FAILURE
BLOOD-OXYGEN LEVEL
QUANTITATIVE-EVALUATION
CALF MUSCLES
LEG
QUANTIFICATION
YOUNG
MEN
CAPILLARIZATION
Summary Impairments in skeletal muscle microvascular function are frequently reported in patients with various cardiometabolic conditions for which older age is a risk factor. Whether aging per se predisposes the skeletal muscle to microvascular dysfunction is unclear. We used contrast‐enhanced ultrasound (CEU) to compare skeletal muscle microvascular perfusion responses to cuff occlusion and leg exercise between healthy young (n = 12, 26 ± 3 years) and older (n = 12, 68 ± 7 years) adults. Test–retest reliability of CEU perfusion parameters was also assessed. Microvascular perfusion (microvascular volume × flow velocity) of the medial gastrocnemius muscle was measured before and immediately after: (a) 5‐min of thigh‐cuff occlusion, and (b) 5‐min of submaximal intermittent isometric plantar‐flexion exercise (400 N) using CEU. Whole‐leg blood flow was measured using strain‐gauge plethysmography. Repeated measures were obtained with a 15‐min interval, and averaged responses were used for comparisons between age groups. There were no differences in post‐occlusion whole‐leg blood flow and muscle microvascular perfusion between young and older participants (p > .05). Similarly, total whole‐leg blood flow during exercise and post‐exercise peak muscle microvascular perfusion did not differ between groups (p > .05). The overall level of agreement between the test–retest measures of calf muscle perfusion was excellent for measurements taken at rest (intraclass correlation coefficient [ICC] 0.85), and in response to cuff occlusion (ICC 0.89) and exercise (ICC 0.95). Our findings suggest that healthy aging does not affect muscle perfusion responses to cuff‐occlusion and submaximal leg exercise. CEU muscle perfusion parameters measured in response to these provocation tests are highly reproducible in both young and older adults.
Language eng
DOI 10.14814/phy2.14580
Indigenous content off
Field of Research 0606 Physiology
1103 Clinical Sciences
1116 Medical Physiology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2020, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30144702

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