Subcortical brain volume, regional cortical thickness and cortical surface area across attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD)

Boedhoe, Premika S. W., van Rooij, Daan, Hoogman, Martine, Twisk, Jos W. R., Schmaal, Lianne, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H., Anikin, Anatoly, Anticevic, Alan, Aherson, Philip, Arango, Celso, Arnold, Paul D., Assogna, Francesca, Auzias, Guillaume, Banaschewski, Tobias, Baranov, Alexander, Batistuzzo, Marcelo C., Baumeister, Sarah, Baur-Streubel, Ramona, Behrmann, Marlene, Silk, Timothy, ENIGMA-ADHD working group, ENIGMA-ASD working group and ENIGMA-OCD working group 2019, Subcortical brain volume, regional cortical thickness and cortical surface area across attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD), bioRxiv, doi: 10.1101/673012.

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Title Subcortical brain volume, regional cortical thickness and cortical surface area across attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD)
Author(s) Boedhoe, Premika S. W.
van Rooij, Daan
Hoogman, Martine
Twisk, Jos W. R.
Schmaal, Lianne
Abe, Yoshinari
Alonso, Pino
Ameis, Stephanie H.
Anikin, Anatoly
Anticevic, Alan
Aherson, Philip
Arango, Celso
Arnold, Paul D.
Assogna, Francesca
Auzias, Guillaume
Banaschewski, Tobias
Baranov, Alexander
Batistuzzo, Marcelo C.
Baumeister, Sarah
Baur-Streubel, Ramona
Behrmann, Marlene
Silk, TimothyORCID iD for Silk, Timothy orcid.org/0000-0002-7290-512X
ENIGMA-ADHD working group
ENIGMA-ASD working group
ENIGMA-OCD working group
Journal name bioRxiv
Total pages 34
Publisher Cold Spring Harbor Laboratory
Place of publication Cold Spring Harbor, N.Y.
Publication date 2019
Keyword(s) the ENIGMA-ADHD working group
the ENIGMA-ASD working group
the ENIGMA-OCD working group
Summary Objective Attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) are common neurodevelopmental disorders that frequently co-occur. We aimed to directly compare all three disorders. The ENIGMA consortium is ideally positioned to investigate structural brain alterations across these disorders.Methods Structural T1-weighted whole-brain MRI of controls (n=5,827) and patients with ADHD (n=2,271), ASD (n=1,777), and OCD (n=2,323) from 151 cohorts worldwide were analyzed using standardized processing protocols. We examined subcortical volume, cortical thickness and surface area differences within a mega-analytical framework, pooling measures extracted from each cohort. Analyses were performed separately for children, adolescents, and adults using linear mixed-effects models adjusting for age, sex and site (and ICV for subcortical and surface area measures).Results We found no shared alterations among all three disorders, while shared alterations between any two disorders did not survive multiple comparisons correction. Children with ADHD compared to those with OCD had smaller hippocampal volumes, possibly influenced by IQ. Children and adolescents with ADHD also had smaller ICV than controls and those with OCD or ASD. Adults with ASD showed thicker frontal cortices compared to adult controls and other clinical groups. No OCD-specific alterations across different age-groups and surface area alterations among all disorders in childhood and adulthood were observed.Conclusion Our findings suggest robust but subtle alterations across different age-groups among ADHD, ASD, and OCD. ADHD-specific ICV and hippocampal alterations in children and adolescents, and ASD-specific cortical thickness alterations in the frontal cortex in adults support previous work emphasizing neurodevelopmental alterations in these disorders.
Language eng
DOI 10.1101/673012
Indigenous content off
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30144919

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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