Subcortical brain volume, regional cortical thickness and cortical surface area across attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) Boedhoe, Premika S. W., van Rooij, Daan, Hoogman, Martine, Twisk, Jos W. R., Schmaal, Lianne, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H., Anikin, Anatoly, Anticevic, Alan, Aherson, Philip, Arango, Celso, Arnold, Paul D., Assogna, Francesca, Auzias, Guillaume, Banaschewski, Tobias, Baranov, Alexander, Batistuzzo, Marcelo C., Baumeister, Sarah, Baur-Streubel, Ramona, Behrmann, Marlene, Silk, Timothy, ENIGMA-ADHD working group, ENIGMA-ASD working group and ENIGMA-OCD working group 2019, Subcortical brain volume, regional cortical thickness and cortical surface area across attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD), bioRxiv, doi: 10.1101/673012. Attached Files Name Description MIMEType Size Downloads Title Subcortical brain volume, regional cortical thickness and cortical surface area across attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) Author(s) Boedhoe, Premika S. W. van Rooij, Daan Hoogman, Martine Twisk, Jos W. R. Schmaal, Lianne Abe, Yoshinari Alonso, Pino Ameis, Stephanie H. Anikin, Anatoly Anticevic, Alan Aherson, Philip Arango, Celso Arnold, Paul D. Assogna, Francesca Auzias, Guillaume Banaschewski, Tobias Baranov, Alexander Batistuzzo, Marcelo C. Baumeister, Sarah Baur-Streubel, Ramona Behrmann, Marlene Silk, Timothy orcid.org/0000-0002-7290-512X ENIGMA-ADHD working group ENIGMA-ASD working group ENIGMA-OCD working group Journal name bioRxiv Total pages 34 Publisher Cold Spring Harbor Laboratory Place of publication Cold Spring Harbor, N.Y. Publication date 2019 Keyword(s) the ENIGMA-ADHD working group the ENIGMA-ASD working group the ENIGMA-OCD working group Summary Objective Attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) are common neurodevelopmental disorders that frequently co-occur. We aimed to directly compare all three disorders. The ENIGMA consortium is ideally positioned to investigate structural brain alterations across these disorders.Methods Structural T1-weighted whole-brain MRI of controls (n=5,827) and patients with ADHD (n=2,271), ASD (n=1,777), and OCD (n=2,323) from 151 cohorts worldwide were analyzed using standardized processing protocols. We examined subcortical volume, cortical thickness and surface area differences within a mega-analytical framework, pooling measures extracted from each cohort. Analyses were performed separately for children, adolescents, and adults using linear mixed-effects models adjusting for age, sex and site (and ICV for subcortical and surface area measures).Results We found no shared alterations among all three disorders, while shared alterations between any two disorders did not survive multiple comparisons correction. Children with ADHD compared to those with OCD had smaller hippocampal volumes, possibly influenced by IQ. Children and adolescents with ADHD also had smaller ICV than controls and those with OCD or ASD. Adults with ASD showed thicker frontal cortices compared to adult controls and other clinical groups. No OCD-specific alterations across different age-groups and surface area alterations among all disorders in childhood and adulthood were observed.Conclusion Our findings suggest robust but subtle alterations across different age-groups among ADHD, ASD, and OCD. ADHD-specific ICV and hippocampal alterations in children and adolescents, and ASD-specific cortical thickness alterations in the frontal cortex in adults support previous work emphasizing neurodevelopmental alterations in these disorders. Language eng DOI 10.1101/673012 Indigenous content off HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2019, The Authors Persistent URL http://hdl.handle.net/10536/DRO/DU:30144919 Document type: Journal Article Collections: Faculty of Health School of Psychology Related Links Link Description Connect to preprint Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Thu, 05 Nov 2020, 07:52:25 EST Fri, 06 Nov 2020, 04:01:14 EST Fri, 06 Nov 2020, 06:22:43 EST Sat, 16 Jan 2021, 05:11:37 EST Wed, 24 Mar 2021, 11:33:00 EST Wed, 24 Mar 2021, 11:39:54 EST Wed, 24 Mar 2021, 13:16:03 EST Thu, 01 Apr 2021, 15:02:51 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 27 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Thu, 05 Nov 2020, 07:52:25 EST

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