Structural neuroplastic responses preserve functional connectivity and neurobehavioural outcomes in children born without corpus callosum

Siffredi, Vanessa, Preti, Maria G, Kebets, Valeria, Obertino, Silvia, Leventer, Richard J, Mcilroy, Alissandra, Wood, Amanda G, Anderson, Vicki, Spencer-Smith, Megan M and Van De Ville, Dimitri 2021, Structural neuroplastic responses preserve functional connectivity and neurobehavioural outcomes in children born without corpus callosum, Cerebral cortex, vol. 31, no. 2, pp. 1227-1239, doi: 10.1093/cercor/bhaa289.

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Title Structural neuroplastic responses preserve functional connectivity and neurobehavioural outcomes in children born without corpus callosum
Author(s) Siffredi, Vanessa
Preti, Maria G
Kebets, Valeria
Obertino, Silvia
Leventer, Richard J
Mcilroy, Alissandra
Wood, Amanda GORCID iD for Wood, Amanda G orcid.org/0000-0002-1537-6858
Anderson, Vicki
Spencer-Smith, Megan M
Van De Ville, Dimitri
Journal name Cerebral cortex
Volume number 31
Issue number 2
Start page 1227
End page 1239
Total pages 13
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2021-02
ISSN 1047-3211
1460-2199
Keyword(s) brain plasticity
callosal agenesis
functional connectivity
structural connectivity
structural reorganization
Summary
The corpus callosum is the largest white matter pathway in the brain connecting the two hemispheres. In the context of developmental absence (agenesis) of the corpus callosum (AgCC), a proposed candidate for neuroplastic response is strengthening of intrahemispheric pathways. To test this hypothesis, we assessed structural and functional connectivity in a uniquely large cohort of children with AgCC (n = 20) compared with typically developing controls (TDC, n = 29), and then examined associations with neurobehavioral outcomes using a multivariate data-driven approach (partial least squares correlation, PLSC). For structural connectivity, children with AgCC showed a significant increase in intrahemispheric connectivity in addition to a significant decrease in interhemispheric connectivity compared with TDC, in line with the aforementioned hypothesis. In contrast, for functional connectivity, children with AgCC and TDC showed a similar pattern of intrahemispheric and interhemispheric connectivity. In conclusion, we observed structural strengthening of intrahemispheric pathways in children born without corpus callosum, which seems to allow for functional connectivity comparable to a typically developing brain, and were relevant to explain neurobehavioral outcomes in this population. This neuroplasticity might be relevant to other disorders of axonal guidance, and developmental disorders in which corpus callosum alteration is observed
Language eng
DOI 10.1093/cercor/bhaa289
Indigenous content off
Field of Research 1109 Neurosciences
1701 Psychology
1702 Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30145199

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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