Solid lipid particle-loaded Ccimum Gratissimum seed films and polymeric films for controlled drug delivery

Mai, Hang D., Tran, H. L. Phuong and Tran, Thao T. D. 2020, Solid lipid particle-loaded Ccimum Gratissimum seed films and polymeric films for controlled drug delivery, Drug Delivery Letters, vol. 10, no. 4, pp. 300-307, doi: 10.2174/2210303110999200811161739.


Title Solid lipid particle-loaded Ccimum Gratissimum seed films and polymeric films for controlled drug delivery
Author(s) Mai, Hang D.
Tran, H. L. PhuongORCID iD for Tran, H. L. Phuong orcid.org/0000-0001-8463-7516
Tran, Thao T. D.
Journal name Drug Delivery Letters
Volume number 10
Issue number 4
Start page 300
End page 307
Total pages 8
Publisher Bentham Science Publishers
Place of publication Sharjah, United Arab Emirates
Publication date 2020-01-01
ISSN 2210-3031
2210-304X
Keyword(s) solid lipid particles
controlled release
sodium fusidate
Ocimum Gratissimum seed
polymeric film
drug delivery
Summary Aims:The purpose of this study was to investigate and compare the formation of polymeric and Ocimum gratissimum seed films containing solid lipid particles for controlled drug release.Methods:The hot homogeneous method was selected to form solid lipid particles containing sodium fusidate to load the drug into the film. The in vitro drug release and drug permeability of the films were tested with dialysis tubes and the Franz diffusion cell method, respectively. The mucoadhesive time and the swelling and erosion rates were also studied.Results:The solid lipid particles showed the ability to form Ocimum gratissimum seed and polymeric films for use in drug delivery. Although the polymeric matrix yielded excellent swelling and erosion rates, leading to a faster drug release rate and drug permeation than that of the Ocimum gratissimum seed film, the mucoadhesive time of the polymer film wasworse than that of the seed film.Conclusion:Therefore, the characteristics of the individual systems may be further studied in a combined system to takefull advantage of both in a desired film.
Language eng
DOI 10.2174/2210303110999200811161739
Indigenous content off
Field of Research 1115 Pharmacology and Pharmaceutical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2020, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30145311

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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