Auditory fear conditioning alters neural gain in the cochlear nucleus: a wireless neural recording study in freely behaving rats Paolini, Antonio G, Morgan, Simeon J and Kim, Jee Hyun 2020, Auditory fear conditioning alters neural gain in the cochlear nucleus: a wireless neural recording study in freely behaving rats, Neuronal signaling, vol. 4, no. 4, pp. 1-11, doi: 10.1042/ns20200009. Attached Files Name Description MIMEType Size Downloads Title Auditory fear conditioning alters neural gain in the cochlear nucleus: a wireless neural recording study in freely behaving rats Author(s) Paolini, Antonio G Morgan, Simeon J Kim, Jee Hyun orcid.org/0000-0002-1299-4300 Journal name Neuronal signaling Volume number 4 Issue number 4 Article ID NS20200009 Start page 1 End page 11 Total pages 11 Publisher Portland Press Limited Place of publication London, Eng. Publication date 2020-12 ISSN 2059-6553 2059-6553 Keyword(s) classical conditioning cochlear nucleus electrophysiology learning and memory neuroplasticity rat Summary Anxiety disorders involve distorted perception of the world including increased saliency of stress-associated cues. However, plasticity in the initial sensory regions of the brain following a fearful experience has never been examined. The cochlear nucleus (CN) is the first station in the central auditory system, with heterogeneous collections of neurons that not only project to but also receive projections from cortico-limbic regions, suggesting a potential for experience-dependent plasticity. Using wireless neural recordings in freely behaving rats, we demonstrate for the first time that neural gain in the CN is significantly altered by fear conditioning to auditory sequences. Specifically, the ventral subnuclei significantly increased firing rate to the conditioned tone sequence, while the dorsal subnuclei significantly decreased firing rate during the conditioning session overall. These findings suggest subregion-specific changes in the balance of inhibition and excitation in the CN as a result of conditioning experience. Heart rate was measured as the conditioned response (CR), which showed that while pre-conditioned stimulus (CS) responding did not change across baseline and conditioning sessions, significant changes in heart rate were observed to the tone sequence followed by shock. Heart-rate findings support acquisition of conditioned fear. Taken together, the present study presents first evidence for potential experience-dependent changes in auditory perception that involve novel plasticity within the first site of processing auditory information in the brain. Language eng DOI 10.1042/ns20200009 Indigenous content off HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30145732 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Link to full-text (open-access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Wed, 25 Nov 2020, 06:57:12 EST Thu, 26 Nov 2020, 04:00:57 EST Thu, 26 Nov 2020, 07:03:11 EST Tue, 08 Dec 2020, 10:02:51 EST Tue, 12 Jan 2021, 05:15:09 EST Mon, 22 Mar 2021, 08:58:01 EST Mon, 22 Mar 2021, 08:59:17 EST Mon, 22 Mar 2021, 14:57:58 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 13 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Tue, 08 Dec 2020, 10:02:51 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.