Combination of Balsamin and Flavonoids Induce Apoptotic Effects in Liver and Breast Cancer Cells Ajji, Parminder K., Walder, Ken and Puri, Munish 2020, Combination of Balsamin and Flavonoids Induce Apoptotic Effects in Liver and Breast Cancer Cells, Frontiers in Pharmacology, vol. 11, pp. 1-13, doi: 10.3389/fphar.2020.574496. Attached Files Name Description MIMEType Size Downloads ajji-combinationofbalsamin-2020.pdf Published version application/pdf 2.19MB 22 Title Combination of Balsamin and Flavonoids Induce Apoptotic Effects in Liver and Breast Cancer Cells Author(s) Ajji, Parminder K. Walder, Ken orcid.org/0000-0002-6758-4763 Puri, Munish orcid.org/0000-0003-2469-3326 Journal name Frontiers in Pharmacology Volume number 11 Article ID 574496 Start page 1 End page 13 Total pages 13 Publisher Frontiers Media Place of publication Lausanne, Switzerland Publication date 2020-10-28 ISSN 1663-9812 1663-9812 Keyword(s) bioactives naringenin naringin quercetin ribosome inactivating proteins therapeutics Science & Technology Life Sciences & Biomedicine Pharmacology & Pharmacy RIBOSOME-INACTIVATING PROTEIN ENDOPLASMIC-RETICULUM STRESS NARINGIN SUPPRESSES HUMAN PROSTATE INHIBITION PATHWAYS PROLIFERATION METABOLISM ARREST Summary Flavonoids such as naringenin, quercetin, and naringin are known to exhibit anticancer properties. In this study, we examined the effects of these flavonoids on cell viability and apoptotic pathways of cancer cells, either singly or in combination with the type 1 ribosome inactivating protein, Balsamin. Treatment with flavonoids (naringenin, quercetin, and naringin) plus Balsamin for 48 h reduced HepG2 and MCF-7 cell viability, increased the activation of caspase-3 and -8, and induced apoptosis through up-regulation of pro-apoptotic genes and down-regulation of anti-apoptotic genes. Out of the three flavonoids tested, the Balsamin-Naringenin and Balsamin-Quercetin combinations appeared to be most effective compared to the Balsamin-Naringin combination. Balsamin combined with flavonoids also activated endoplasmic reticulum (ER)-stress–mediated apoptosis in breast cancer (MCF-7) cells, which was not activated by Balsamin treatment alone. These experimental results showed that Balsamin combined with flavonoids can reduce HepG2 and MCF-7 cells viability and induce apoptosis, which could be considered as a promising therapeutic approach to sensitize cells to Balsamin treatment, thereby improving its efficacy in breast or liver cancer therapy. Language eng DOI 10.3389/fphar.2020.574496 Indigenous content off Field of Research 1115 Pharmacology and Pharmaceutical Sciences HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2020, Ajji, Walder and Puri Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30145927 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Link to full-text (open access)     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Fri, 27 Nov 2020, 07:08:03 EST Sat, 28 Nov 2020, 04:01:05 EST Mon, 30 Nov 2020, 06:58:43 EST Sat, 09 Jan 2021, 01:40:27 EST Tue, 12 Jan 2021, 05:22:10 EST Mon, 25 Jan 2021, 14:16:15 EST Mon, 25 Jan 2021, 14:17:57 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 36 Abstract Views, 22 File Downloads  -  Detailed Statistics Created: Fri, 27 Nov 2020, 07:08:03 EST

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