Telomere length in subjects with schizophrenia, their unaffected siblings and healthy controls: Evidence of accelerated aging

Czepielewski, Leticia Sanguinetti, Massuda, Raffael, Panizzutti, Bruna, da Rosa, Eduarda Dias, de Lucena, David, Macêdo, Danielle, Grun, Lucas Kich, Barbé-Tuana, Florencia María and Gama, Clarissa Severino 2016, Telomere length in subjects with schizophrenia, their unaffected siblings and healthy controls: Evidence of accelerated aging, Schizophrenia Research, vol. 174, no. 1-3, pp. 39-42, doi: 10.1016/j.schres.2016.04.004.

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Title Telomere length in subjects with schizophrenia, their unaffected siblings and healthy controls: Evidence of accelerated aging
Author(s) Czepielewski, Leticia Sanguinetti
Massuda, Raffael
Panizzutti, Bruna
da Rosa, Eduarda Dias
de Lucena, David
Macêdo, Danielle
Grun, Lucas Kich
Barbé-Tuana, Florencia María
Gama, Clarissa Severino
Journal name Schizophrenia Research
Volume number 174
Issue number 1-3
Start page 39
End page 42
Total pages 4
Publisher Elsevier BV
Place of publication Amsterdam, Netherlands
Publication date 2016-07-01
ISSN 0920-9964
1573-2509
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Psychiatry
Schizophrenia
Telomere length
Accelerated aging
Endophenotypes
Biomarkers
ACID REACTIVE SUBSTANCES
SERUM SUPEROXIDE-DISMUTASE
PSYCHIATRIC-DISORDERS
BIPOLAR DISORDER
METAANALYSIS
HYPOTHESIS
CYTOKINES
DISEASE
Summary Schizophrenia (SZ) is associated with broad burden. The clinical manifestations of SZ are related to pathophysiological alterations similar to what is seen in normal aging. Our aim was to evaluate the differences in telomere length (TL), a biomarker of cellular aging, in subjects with SZ (n = 36), unaffected siblings (SB, n = 36) and healthy controls (HC, n = 47). SZ had shorter TL compared to HC, but no difference was found in SB comparing to SZ. These findings indicate that a pathological accelerated aging profile could be present in the course of SZ and further studies are needed to confirm TL as potential endophenotype, especially in at risk populations.
Language eng
DOI 10.1016/j.schres.2016.04.004
Indigenous content off
Field of Research 11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2016, Elsevier BV
Persistent URL http://hdl.handle.net/10536/DRO/DU:30146067

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