Exercise alters cardiovascular and renal pregnancy adaptations in female rats born small on a high-fat diet Mahizir, Dayana, Briffa, Jessica F., Anevska, Kristina, Wadley, Glenn D., Mortiz, Karen M. and Wlodek, Mary E. 2021, Exercise alters cardiovascular and renal pregnancy adaptations in female rats born small on a high-fat diet, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol. 320, no. 4, pp. R404-R416, doi: 10.1152/ajpregu.00260.2020. Attached Files Name Description MIMEType Size Downloads Title Exercise alters cardiovascular and renal pregnancy adaptations in female rats born small on a high-fat diet Author(s) Mahizir, Dayana Briffa, Jessica F. Anevska, Kristina Wadley, Glenn D. orcid.org/0000-0002-6617-4359 Mortiz, Karen M. Wlodek, Mary E. Journal name American Journal of Physiology-Regulatory, Integrative and Comparative Physiology Volume number 320 Issue number 4 Start page R404 End page R416 Total pages 13 Publisher American Physiological Society Place of publication Bethesda, Md. Publication date 2021-04 ISSN 0363-6119 1522-1490 Keyword(s) blood pressure growth restriction pregnancy renal function Summary Intrauterine growth restriction programs adult cardiorenal disease, which may be exacerbated by pregnancy and obesity. Importantly, exercise has positive cardiovascular effects. This study determined if high-fat-feeding exacerbates the known adverse cardiorenal adaptations to pregnancy in rats born small and whether endurance exercise can prevent these complications. Uteroplacental insufficiency was induced by bilateral uterine vessel ligation (Restricted) or sham (Control) surgery on embryonic day 18 (E18) in Wistar-Kyoto rats. Female offspring consumed a Chow or High-fat-diet (HFD) from weaning and were randomly allocated an exercise protocol at 16 weeks; Sedentary, Exercised before and during pregnancy (Exercise), or Exercised during pregnancy only (PregEx). Systolic blood pressure was measured pre-pregnancy and rats were mated at 20 weeks. During pregnancy, systolic blood pressure (E18) and renal function (E19) were assessed. Sedentary HFD Control females had increased estimated glomerular filtration rate (eGFR) compared to Chow. Compared to Control, Sedentary Restricted females had increased eGFR, which was not influenced by HFD. Renal function was not affected by exercise and pre-pregnancy blood pressure was not altered. Restricted Chow-fed dams and dams fed a high-fat-diet had a greater reduction in systolic blood pressure during late gestation, which was only prevented by Exercise. In summary, high-fat fed females born small are at a greater risk of altered cardiorenal adaptations to pregnancy. Although cardiovascular dysfunction was prevented by Exercise, renal dysfunction was not affected by exercise interventions. This study highlights that modifiable risk factors can have beneficial effects in the mother during pregnancy, which may impact fetal growth and development. Language eng DOI 10.1152/ajpregu.00260.2020 Indigenous content off Field of Research 111699 Medical Physiology not elsewhere classified 06 Biological Sciences 11 Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30146336 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Open Access Collection Related Links Link Description Link to full-text (open access)     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Tue, 22 Dec 2020, 09:43:29 EST Wed, 23 Dec 2020, 04:00:42 EST Tue, 29 Dec 2020, 15:20:45 EST Fri, 05 Mar 2021, 05:03:28 EST Mon, 08 Mar 2021, 13:59:27 EST Mon, 08 Mar 2021, 14:02:14 EST Mon, 08 Mar 2021, 14:49:40 EST Wed, 07 Apr 2021, 10:20:15 EST Wed, 07 Apr 2021, 10:20:53 EST Wed, 07 Apr 2021, 10:23:32 EST Sat, 17 Apr 2021, 02:32:22 EST Sat, 17 Apr 2021, 18:35:56 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 42 Abstract Views, 1 File Downloads  -  Detailed Statistics Created: Tue, 22 Dec 2020, 09:43:29 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.