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Novel detection of nasty bugs, prevention is better than cure

Strom, Mia, Crowley, Tamsyn and Shigdar, Sarah 2021, Novel detection of nasty bugs, prevention is better than cure, International journal of molecular sciences, vol. 22, no. 1, pp. 1-19, doi: 10.3390/ijms22010149.

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Title Novel detection of nasty bugs, prevention is better than cure
Author(s) Strom, Mia
Crowley, TamsynORCID iD for Crowley, Tamsyn orcid.org/0000-0002-3698-8917
Shigdar, SarahORCID iD for Shigdar, Sarah orcid.org/0000-0001-8084-8447
Journal name International journal of molecular sciences
Volume number 22
Issue number 1
Article ID 149
Start page 1
End page 19
Total pages 19
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2021-01-01
ISSN 1661-6596
1422-0067
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemistry & Molecular Biology
Chemistry, Multidisciplinary
Chemistry
aptamers
detection systems
hospital-acquired infections
Summary Hospital-acquired infections (HAIs) are a growing concern around the world. They contribute to increasing mortality and morbidity rates and are an economic threat. All hospital patients have the potential to contract an HAI, but those with weakened or inferior immune systems are at highest risk. Most hospital patients will contract at least one HAI, but many will contract multiple ones. Bacteria are the most common cause of HAIs and contribute to 80–90% of all HAIs, with Staphylococcus aureus, Clostridium difficile, Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae accounting for the majority. Each of these bacteria are highly resistant to antibiotics and can produce a protective film, known as a biofilm, to further prevent their eradication. It has been shown that by detecting and eradicating bacteria in the environment, infection rates can be reduced. The current methods for detecting bacteria are time consuming, non-specific, and prone to false negatives or false positives. Aptamer-based biosensors have demonstrated specific, time-efficient and simple detection, highlighting the likelihood that they could be used in a similar way to detect HAI-causing bacteria.
Language eng
DOI 10.3390/ijms22010149
Indigenous content off
Field of Research 0399 Other Chemical Sciences
0604 Genetics
0699 Other Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30146541

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.