Effects of Mucoadhesive Polymers on Released Particles and Drug Release in Solid Lipid Particle-Based Buccal Tablets

Phan, TTH, Tran, Ha Lien Phuong and Tran, TTD 2020, Effects of Mucoadhesive Polymers on Released Particles and Drug Release in Solid Lipid Particle-Based Buccal Tablets, Anti-Cancer Agents in Medicinal Chemistry, doi: 10.2174/1871520621666201207091827.


Title Effects of Mucoadhesive Polymers on Released Particles and Drug Release in Solid Lipid Particle-Based Buccal Tablets
Author(s) Phan, TTH
Tran, Ha Lien PhuongORCID iD for Tran, Ha Lien Phuong orcid.org/0000-0001-8463-7516
Tran, TTD
Journal name Anti-Cancer Agents in Medicinal Chemistry
Publisher Bentham Science Publishers Ltd.
Place of publication Schiphol, The Netherlands
Publication date 2020-12-07
ISSN 1871-5206
1875-5992
Keyword(s) Poorly water-soluble drugs
buccal tablet
controlled release
mucoadhesive polymer
prednisolone.
solid lipid particles
Summary Background: Mucoadhesive polymers play a critical role in controlled release tablets for buccal drug delivery.Objective: This research aimed to investigate the characterization and mechanisms of solid lipid particle-based tablets with differentmucoadhesive polymers for buccal delivery.Methods: Prednisolone (PSL)-loaded solid lipid particles (SLPs) were conventionally prepared by ultrasonication. The freeze-dryingmethod was used to convert the SLP suspension into a solid dosage form for buccal delivery by using mucoadhesive polymers.Results:All formulations showed over 80% drug release after 6 h, which followed immediate and sustained release patterns depending onthe SLP type. However, the different polymers in the formulations resulted in different mucoadhesion times and drug release and drugpermeability profiles. HPMC 4000 showed higher drug permeation (3327 μg vs. 2589 μg after 6 h) but a shorter mucoadhesion time thanCarbopol (197 min vs. 361 min). In addition, surface morphology, swelling and erosion, particle size and zeta potential were also noted forthe different mechanisms for buccal tablet design with different controlled release profiles.Conclusion:The results of this work indicate a good strategy for the selection of mucoadhesive polymers for SLP-based tablets inimproving the bioavailability of poorly water-soluble drugs.
Notes In Press
Language eng
DOI 10.2174/1871520621666201207091827
Indigenous content off
Field of Research 0304 Medicinal and Biomolecular Chemistry
1112 Oncology and Carcinogenesis
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30146697

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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