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Lesion induced error on automated measures of brain volume: data from a pediatric traumatic brain injury cohort

King, Daniel J, Novak, Jan, Shephard, Adam J, Beare, Richard, Anderson, Vicki A and Wood, Amanda G 2020, Lesion induced error on automated measures of brain volume: data from a pediatric traumatic brain injury cohort, Frontiers in neuroscience, vol. 14, pp. 1-13, doi: 10.3389/fnins.2020.491478.

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Title Lesion induced error on automated measures of brain volume: data from a pediatric traumatic brain injury cohort
Author(s) King, Daniel J
Novak, Jan
Shephard, Adam J
Beare, Richard
Anderson, Vicki A
Wood, Amanda GORCID iD for Wood, Amanda G orcid.org/0000-0002-1537-6858
Journal name Frontiers in neuroscience
Volume number 14
Article ID 491478
Start page 1
End page 13
Total pages 13
Publisher Frontiers Research Foundation
Place of publication Lausanne, Switzerland
Publication date 2020-11-30
ISSN 1662-4548
1662-453X
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
traumatic brain injury
lesion
FreeSurfer
morphometry
pediatric
methods
Summary Structural segmentation of T1-weighted (T1w) MRI has shown morphometric differences, both compared to controls and longitudinally, following a traumatic brain injury (TBI). While many patients with TBI present with abnormalities on structural MRI images, most neuroimaging software packages have not been systematically evaluated for accuracy in the presence of these pathology-related MRI abnormalities. The current study aimed to assess whether acute MRI lesions (MRI acquired 7–71 days post-injury) cause error in the estimates of brain volume produced by the semi-automated segmentation tool, Freesurfer. More specifically, to investigate whether this error was global, the presence of lesion-induced error in the contralesional hemisphere, where no abnormal signal was present, was measured. A dataset of 176 simulated lesion cases was generated using actual lesions from 16 pediatric TBI (pTBI) cases recruited from the emergency department and 11 typically-developing controls. Simulated lesion cases were compared to the “ground truth” of the non-lesion control-case T1w images. Using linear mixed-effects models, results showed that hemispheric measures of cortex volume were significantly lower in the contralesional-hemisphere compared to the ground truth. Interestingly, however, cortex volume (and cerebral white matter volume) were not significantly different in the lesioned hemisphere. However, percent volume difference (PVD) between the simulated lesion and ground truth showed that the magnitude of difference of cortex volume in the contralesional-hemisphere (mean PVD = 0.37%) was significantly smaller than that in the lesioned hemisphere (mean PVD = 0.47%), suggesting a small, but systematic lesion-induced error. Lesion characteristics that could explain variance in the PVD for each hemisphere were investigated. Taken together, these results suggest that the lesion-induced error caused by simulated lesions was not focal, but globally distributed. Previous post-processing approaches to adjust for lesions in structural analyses address the focal region where the lesion was located however, our results suggest that focal correction approaches are insufficient for the global error in morphometric measures of the injured brain.
Language eng
DOI 10.3389/fnins.2020.491478
Indigenous content off
Field of Research 1109 Neurosciences
1701 Psychology
1702 Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30146711

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.