Adjunctive Garcinia mangostana Linn. (Mangosteen) pericarp for Schizophrenia: A 24-week double-blind, randomized, placebo controlled efficacy trial Péricarpe d’appoint Garcinia mangostana Linn (mangoustan) pour la schizophrénie : un essai d’efficaci

Turner, Alyna, Baker, Andrea, Dean, Olivia M., Walker, Adam J., Dodd, Seetal, Cotton, Susan M., Scott, James G., Kavanagh, Bianca E., Ashton, Melanie M., Brown, Ellie, McGrath, John J. and Berk, Michael 2020, Adjunctive Garcinia mangostana Linn. (Mangosteen) pericarp for Schizophrenia: A 24-week double-blind, randomized, placebo controlled efficacy trial Péricarpe d’appoint Garcinia mangostana Linn (mangoustan) pour la schizophrénie : un essai d’efficacité de 24 semaines, à double insu, randomisé et contrôlé par placebo, The Canadian Journal of Psychiatry, doi: 10.1177/0706743720982437.

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Title Adjunctive Garcinia mangostana Linn. (Mangosteen) pericarp for Schizophrenia: A 24-week double-blind, randomized, placebo controlled efficacy trial Péricarpe d’appoint Garcinia mangostana Linn (mangoustan) pour la schizophrénie : un essai d’efficacité de 24 semaines, à double insu, randomisé et contrôlé par placebo
Author(s) Turner, AlynaORCID iD for Turner, Alyna orcid.org/0000-0001-7389-2546
Baker, Andrea
Dean, Olivia M.ORCID iD for Dean, Olivia M. orcid.org/0000-0002-2776-3935
Walker, Adam J.ORCID iD for Walker, Adam J. orcid.org/0000-0002-5399-1245
Dodd, SeetalORCID iD for Dodd, Seetal orcid.org/0000-0002-7918-4636
Cotton, Susan M.
Scott, James G.
Kavanagh, Bianca E.ORCID iD for Kavanagh, Bianca E. orcid.org/0000-0002-1656-2775
Ashton, Melanie M.ORCID iD for Ashton, Melanie M. orcid.org/0000-0001-6832-4157
Brown, Ellie
McGrath, John J.
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name The Canadian Journal of Psychiatry
Total pages 13
Publisher SAGE Publications
Place of publication Thousand Oaks, Calif.
Publication date 2020-12-23
ISSN 0706-7437
1497-0015
Keyword(s) Garcinia mangostana Linn
clinical trial
inflammation
mangosteen
mental disorders
oxidative stress
psychiatry
schizoaffective disorder
schizophrenia
treatment
Summary Objectives:Garcinia mangostana Linn. (“mangosteen”) pericarp contains bioactive compounds that may target biological pathways implicated in schizophrenia. We conducted a double-blind randomized placebo-controlled trial evaluating the efficacy of adjunctive mangosteen pericarp, compared to placebo, in the treatment of schizophrenia. Methods: People diagnosed with schizophrenia or schizoaffective disorder ( Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition), recruited across 2 sites (Brisbane and Victoria, Australia), were randomized to receive 24 weeks of adjunctive mangosteen pericarp (1,000 mg/day) or matched placebo. The primary outcome measure was the Positive and Negative Symptom Scale total score. Secondary outcomes included positive and negative symptoms, general psychopathology, clinical global severity and improvement, participant reported overall improvement, depressive symptoms, functioning, quality of life, and safety data at 24 and 28 weeks (4 weeks postdiscontinuation). Data were collected from July 2016 to February 2019. Results: Baseline assessments were conducted on 148 people (mangosteen = 74, placebo = 74); data analyses were conducted on 136 (92%) participants with postbaseline data. The treatment group had significantly higher symptom severity compared to placebo, and both groups significantly improved on all symptom, functioning, and quality of life measures over time. No between-group differences were found for the rate of change between baseline and 24 or 28 weeks.Conclusion: Despite promising preclinical and clinical work, our results do not support mangosteen pericarp extract as an adjunctive treatment for schizophrenia or schizoaffective disorder.
Language eng
DOI 10.1177/0706743720982437
Indigenous content off
Field of Research 11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2020, The Author
Persistent URL http://hdl.handle.net/10536/DRO/DU:30146979

Document type: Journal Article
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School of Medicine
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