Skeletal muscle health and cognitive function: a narrative review Sui, Sophia X., Williams, Lana J., Holloway-Kew, Kara L., Hyde, Natalie K. and Pasco, Julie A. 2021, Skeletal muscle health and cognitive function: a narrative review, International journal of molecular sciences, vol. 22, no. 1, pp. 1-22, doi: 10.3390/ijms22010255. Attached Files Name Description MIMEType Size Downloads Title Skeletal muscle health and cognitive function: a narrative review Author(s) Sui, Sophia X. Williams, Lana J. orcid.org/0000-0002-1377-1272 Holloway-Kew, Kara L. Hyde, Natalie K. orcid.org/0000-0002-0693-2904 Pasco, Julie A. orcid.org/0000-0002-8968-4714 Journal name International journal of molecular sciences Volume number 22 Issue number 1 Article ID 255 Start page 1 End page 22 Total pages 22 Publisher MDPI Place of publication Basel, Switzerland Publication date 2021 ISSN 1661-6596 1422-0067 Keyword(s) Science & Technology Life Sciences & Biomedicine Physical Sciences Biochemistry & Molecular Biology Chemistry, Multidisciplinary Chemistry skeletal muscle health sarcopenia cognitive function dementia cognitive decline cognitive impairment vitamin D inflammation oxidative stress lifestyle risk factors GAIT SPEED DECLINE OLDER-ADULTS BODY-COMPOSITION ALZHEIMERS-DISEASE GRIP STRENGTH ELDERLY-WOMEN VITAMIN-D INFLAMMATORY MARKERS EXECUTIVE FUNCTION HANDGRIP STRENGTH Summary Sarcopenia is the loss of skeletal muscle mass and function with advancing age. It involves both complex genetic and modifiable risk factors, such as lack of exercise, malnutrition and reduced neurological drive. Cognitive decline refers to diminished or impaired mental and/or intellectual functioning. Contracting skeletal muscle is a major source of neurotrophic factors, including brain-derived neurotrophic factor, which regulate synapses in the brain. Furthermore, skeletal muscle activity has important immune and redox effects that modify brain function and reduce muscle catabolism. The identification of common risk factors and underlying mechanisms for sarcopenia and cognition may allow the development of targeted interventions that slow or reverse sarcopenia and also certain forms of cognitive decline. However, the links between cognition and skeletal muscle have not been elucidated fully. This review provides a critical appraisal of the literature on the relationship between skeletal muscle health and cognition. The literature suggests that sarcopenia and cognitive decline share pathophysiological pathways. Ageing plays a role in both skeletal muscle deterioration and cognitive decline. Furthermore, lifestyle risk factors, such as physical inactivity, poor diet and smoking, are common to both disorders, so their potential role in the muscle–brain relationship warrants investigation. Language eng DOI 10.3390/ijms22010255 Indigenous content off Field of Research 0399 Other Chemical Sciences 0604 Genetics 0699 Other Biological Sciences HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30147048 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Link to full-text (open access)     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Wed, 13 Jan 2021, 11:08:38 EST Wed, 13 Jan 2021, 13:15:46 EST Wed, 13 Jan 2021, 13:30:44 EST Thu, 14 Jan 2021, 07:44:27 EST Sat, 16 Jan 2021, 01:42:44 EST Tue, 02 Mar 2021, 05:06:58 EST Sat, 06 Mar 2021, 01:34:33 EST Mon, 08 Mar 2021, 13:19:55 EST Mon, 08 Mar 2021, 13:23:26 EST Mon, 08 Mar 2021, 13:24:02 EST Filtered Full Citation counts:   Cited 2 times in TR Web of Science Cited 2 times in Scopus Search Google Scholar Access Statistics: 23 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Wed, 13 Jan 2021, 11:08:38 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.