Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women Pasco, Julie A., Stuart, Amanda L., Sui, Sophia X., Holloway-Kew, Kara L., Hyde, Natalie K., Tembo, Monica C., Rufus-Membere Pamela, Kotowicz, Mark A. and Williams, Lana J. 2021, Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women, Journal of Clinical Medicine, vol. 10, no. 2, pp. 1-7, doi: 10.3390/jcm10020173. Attached Files Name Description MIMEType Size Downloads Title Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women Author(s) Pasco, Julie A. orcid.org/0000-0002-8968-4714 Stuart, Amanda L. orcid.org/0000-0001-8770-9511 Sui, Sophia X. orcid.org/0000-0001-6388-1261 Holloway-Kew, Kara L. orcid.org/0000-0001-5064-2990 Hyde, Natalie K. orcid.org/0000-0002-0693-2904 Tembo, Monica C. orcid.org/0000-0003-1210-2437 Rufus-Membere Pamela Kotowicz, Mark A. orcid.org/0000-0002-8094-1411 Williams, Lana J. orcid.org/0000-0002-1377-1272 Journal name Journal of Clinical Medicine Volume number 10 Issue number 2 Article ID 173 Start page 1 End page 7 Total pages 7 Publisher MDPI AG Place of publication Basel, Switzerland Publication date 2021-01-06 ISSN 2077-0383 2077-0383 Keyword(s) brain-body cross-talk cognition muscle strength older persons sarcopenia Summary Dynapenia is a key contributor to physical frailty. Cognitive impairment and dementia accompany frailty, yet links between skeletal muscle and neurocognition are poorly understood. We examined the cross-sectional relationship between lower limb muscle strength and global cognitive function. Participants were 127 women aged 51–87 years, from the Geelong Osteoporosis Study. Peak eccentric strength of the hip-flexors and hip abductors was determined using a hand-held dynamometer, and dynapenia identified as muscle strength t-scores < −1. Cognition was assessed using the Mini-Mental State Examination (MMSE), and MMSE scores below the median were rated as low. Associations between dynapenia and low cognition were examined using logistic regression models. Hip-flexor dynapenia was detected in 38 (71.7%) women with low cognition and 36 (48.7%) with good cognition (p = 0.009); for hip abductor dynapenia, the pattern was similar (21 (39.6%) vs. 9 (12.2%); p < 0.001). While the observed difference for hip-flexor strength was attenuated after adjusting for age and height (adjusted Odds Ratio (OR) 1.95, 95%CI 0.86–4.41), low cognition was nearly 4-fold more likely in association with hip abductor dynapenia (adjusted OR 3.76, 95%CI 1.44–9.83). No other confounders were identified. Our data suggest that low strength of the hip abductors and low cognition are associated and this could be a consequence of poor muscle function contributing to cognitive decline or vice versa. As muscle weakness is responsive to physical interventions, this warrants further investigation. Language eng DOI 10.3390/jcm10020173 Indigenous content off Field of Research 1103 Clinical Sciences HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30147262 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Institute for Innovation in Mental and Physical Health and Clinical Translation Related Links Link Description Link to full-text (open access)     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Fri, 15 Jan 2021, 07:37:23 EST Sat, 16 Jan 2021, 04:01:42 EST Mon, 18 Jan 2021, 07:02:45 EST Tue, 19 Jan 2021, 05:08:16 EST Wed, 20 Jan 2021, 14:52:58 EST Wed, 20 Jan 2021, 14:57:20 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 57 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Fri, 15 Jan 2021, 07:37:23 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.