File(s) under permanent embargo
A head mountable deep brain stimulation device for laboratory animals
chapterposted on 2011-01-01, 00:00 authored by Abbas KouzaniAbbas Kouzani, Susannah Tye, Ken WalderKen Walder, Lingxue KongLingxue Kong
Deep brain stimulation has emerged as an effective method to treat certain medical conditions. Electrical charges are injected into the target tissue through a conducting electrode exciting the tissue. A variety of DBS devices have been developed based on different operation principles. Majority of these devices, however, employ complex circuitry and are bulky. In clinical trials, laboratory animals need to freely move around and perform activities whilst receiving brain stimulation for days. This paper presents a simple lightweight head mountable deep brain stimulation device that can be carried by the animal during the course of a clinical trial. The device produces continuous current pulses of specific characteristics. It employs passive charge balancing to minimize undesirable effects on the target tissue. The device is constructed and its performance tested.