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An Alternate View of Neuroprotection with Peptides in Alzheimer’s Disease

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posted on 2024-10-03, 11:25 authored by Samuel KingSamuel King, Cenk SuphiogluCenk Suphioglu
Neuroprotection plays a crucial role in everyday life, maintaining a clean environment in the central nervous system to allow for normal functioning. In Alzheimer’s disease and other neurodegenerative disorders, neuroprotection may have two roles. Under standard circumstances, the immune system protects the CNS, but sometimes it can exacerbate the pathophysiology of some diseases through neuroinflammation leading to further degeneration. Alzheimer’s disease is fast getting out of control, with no new approvals in therapeutics since 2003, and of those approved, all target symptomatic treatment. Initiated by a microglial response to Aβ plaques, therapeutic development should focus on the amyloid cascade as a neuroprotective measure for Alzheimer’s disease. This chapter will examine the status of the types of therapeutics in clinical trials for Alzheimer’s disease, offering insights into peptides as an area of opportunity for neuroprotection and detailing considerations for the use of peptides in Alzheimer’s disease.

History

Chapter number

2

Pagination

1-1

ISBN-13

9781838804398

Language

eng

Publication classification

B1 Book chapter

Extent

16

Editor/Contributor(s)

Otero-Losada M, Capani F, Perez Lloret S

Publisher

IntechOpen

Place of publication

[Online]

Title of book

Neuroprotection - New Approaches and Prospects

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