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Copper : effects of deficiency and overload

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posted on 2013-01-01, 00:00 authored by I Scheiber, R Dringen, Julian MercerJulian Mercer
Copper is an essential trace metal that is required for the catalysis of several important cellular enzymes. However, since an excess of copper can also harm cells due to its potential to catalyze the generation of toxic reactive oxygen species, transport of copper and the cellular copper content are tightly regulated. This chapter summarizes the current knowledge on the importance of copper for cellular processes and on the mechanisms involved in cellular copper uptake, storage and export. In addition, we will give an overview on disturbances of copper homeostasis that are characterized by copper overload or copper deficiency or have been connected with neurodegenerative disorders. © Springer Science+Business Media Dordrecht 2013.

History

Title of book

Interrelations between essential metal ions and human diseases

Series

Metal ions in life sciences ; v.13.

Chapter number

11

Pagination

359 - 387

Publisher

Springer

Place of publication

Berlin, Germany

ISBN-13

9789400774995

Language

eng

Publication classification

B1.1 Book chapter

Copyright notice

2013, Springer

Extent

16

Editor/Contributor(s)

A Sigel, H Sigel, R Sigel

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