Effects of Salvia miltiorrhiza after acute myocardial infarction in rats
chapter
posted on 2004-01-01, 00:00authored byX Y Ji, B H Tan, S H Huang, M Whiteman, Y C Zhu, Wei DuanWei Duan, Y Z Zhu, W Linz
Acute myocardial infarction (M!) is the commonest cause of death in the developed countries, and it is on the rise in developing countries. Ramipril is a well-knownAngiotensin-converting enzyme (ACE) inhibitorwhich inhibits conversion ofinactive angiotensin I to active angiotensin II. Experimental studies have shown thatACE inhibitors administered chronicallybefore acuteMImight limitmyocardial infarct size, improve cardiac function and prevent cardiac hypertrophy [1, 2]. The Chinese herb, Salvia miltiorrhiza (SM), has been widely and successfully usedmainly for anginapectoris,MI and stroke [3]. Compared to ramipril, however, there is very limited biochemical information availableto demonstrate themechanismsofSMs cardio-protective effects. This study thus investigates the possible biochemical and molecularmechanisms ofsuch effects ofSMin Wistar rats in comparison with those oframipril.
History
Title of book
Novel compounds from natural products in the new millennium